Senior Enterprise AI Engineer: Build Production-Grade Agents

handshake; San Francisco (CA); On-site; USD 170,000 - 230,000; Full time

Benefits offered by this job

Equity

401(k) match

Parental leave

Health benefits (medical, dental, visо

Wellness stipend

Learning stipend

Remote & SF office support

Flexible PTO

Job summary

Handshake is seeking a Senior Applied AI Engineer to embed inside enterprise customer environments in San Francisco. You will own the full stack—from defining the solution to deploying AI agents and evaluating performance—while becoming a domain expert in the customer's vertical.

This is a hands-on, production-focused role requiring deep backend and AI experience, strong stakeholder communication, and a high ownership mindset. Join a fast-moving founding team focused on real-world impact.

Qualifications

• 5-6+ years of engineering experience with strong applied AI and backend depth.
• Real-world production AI applications experience, not just prototyping.
• Strong understanding of agent architectures, evals, and how to measure and improve AI performance.
• Comfort working directly with enterprise customers in high-stakes environments.
• Strong systems thinking from business problems to technical solutions.
• High ownership mentality and outcome-focused mindset.
• Strong communication skills with senior stakeholders.

Responsibilities

• Embed directly with enterprise customers as part of a small deployment team and build deep understanding of their workflows.
• Define AI-driven solutions based on real business needs, not theoretical use cases.
• Build and deploy production-grade agents tailored to customer use cases and own end-to-end delivery.
• Design and run evals to measure agent performance and iterate to improve results.
• Become a domain expert in the customer's vertical and apply that knowledge to AI improvements over time.
• Collaborate with Product and Platform engineers to ship cohesive, reliable solutions.
• Establish engineering best practices and reusable frameworks to scale output without sacrificing quality.
• Surface deployment insights to inform Handshake's platform and roadmap.

Skills

Applied AI

Backend depth

Agent architectures

Customer facing

Systems thinking

Ownership mentality

Communication skills

Job description

Handshake is seeking a Senior Applied AI Engineer to embed inside enterprise customer environments in San Francisco. You will own the full stack—from defining the solution to deploying AI agents and evaluating performance—while becoming a domain expert in the customer's vertical.

This is a hands-on, production-focused role requiring deep backend and AI experience, strong stakeholder communication, and a high ownership mindset. Join a fast-moving founding team focused on real-world impact.