Senior Downstream Processing Engineer – Scale-Up Biologics

Initial Therapeutics, Inc.; Boston (MA); On-site; USD 113,000 - 165,000; Full time

Benefits offered by this job

401(k) plan

Health benefits

Vacation benefits

Job summary

Lilly’s Harborside location in Boston, MA seeks a Principal Engineer, Downstream Processing to support tech transfer for small-scale purification to manufacturing scale and lead downstream analyses including yield, chromatogram interpretation, and troubleshooting.

The role requires deep expertise in downstream unit operations and collaboration with development teams to ensure well‑understood, robust processes are transferred. Some after‑hours flexibility may be needed.

Qualifications

• BS degree in biology, chemistry, biochemistry, chemical engineering, or similar discipline with at least 5 years of relevant experience in downstream scale‑up/scale‑down process development.
• MS degree in biology, chemistry, biochemistry, chemical engineering, or similar discipline with at least 3 years of relevant experience in downstream scale‑up/scale‑down process development.
• PhD will not be considered at this job level
• Qualified applicants must be authorized to work in the United States on a full‑time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F‑1 CPT, F‑1 OPT, F‑1 STEM OPT, J‑1, H‑1B, TN, O‑1, E‑3, H‑1B1, or L‑1.

Responsibilities

• Possess in‑depth knowledge and demonstrated technical capability with downstream unit operations including depth filtration, multiple chromatography modes (e.g., affinity, ion exchange, hydrophobic interaction), ultracentrifugation, and tangential flow filtration (TFF).
• Collaborate with early and late‑phase development organizations to ensure well‑understood and robust processes are transferred.
• Maintain accurate records and interpret data to provide detailed information and analyses.
• Troubleshoot issues as they occur and identify trends and opportunities to reduce process variability and improve product recovery and quality.
• Create and review documents including laboratory SOPs, material specifications, protocols, and work instructions.
• Flexibility to accept new projects, prioritizations, and challenges.

Skills

Downstream processing

Tech transfer

Chromatography

Data analysis

Education

BS degree in biology/chemistry/biochemistry/chemical engineering

MS degree in biology/chemistry/biochemistry/chemical engineering

PhD not considered

Tools

Unicorn software

Microsoft Office

JMP

Job description

Lilly’s Harborside location in Boston, MA seeks a Principal Engineer, Downstream Processing to support tech transfer for small-scale purification to manufacturing scale and lead downstream analyses including yield, chromatogram interpretation, and troubleshooting.

The role requires deep expertise in downstream unit operations and collaboration with development teams to ensure well‑understood, robust processes are transferred. Some after‑hours flexibility may be needed.