Lead Downstream Processing Engineer

Eli Lilly and Company; Boston (MA); On-site; USD 113,000 - 165,000; Full time

Benefits offered by this job

401(k)

Pension

Vacation

Medical benefits

Well-being program

Flexible benefits

Life insurance

Job summary

Eli Lilly and Company is expanding its genetic medicines pipeline at the Harborside location in Boston, MA. The Principal Engineer, Downstream Processing will support tech transfer of small-scale purification to manufacturing scale, performing analyses on yield, chromatograms, filtration, and troubleshooting across unit operations.

The role requires deep technical expertise, collaboration with development teams, and the ability to define the downstream technical agenda in the laboratory.

Qualifications

• BS or MS in biology, chemistry, biochemistry, chemical engineering or similar with relevant downstream scale-up experience.
• MS with at least 3 years of relevant experience; PhD not considered for this level.
• Authorized to work in the United States on a full-time basis; visa sponsorship not provided.

Responsibilities

• Deep knowledge of downstream unit operations (depth filtration, chromatography modes, ultracentrifugation, tangential flow filtration).
• Collaborate with development groups to ensure robust transfer to manufacturing scale.
• Maintain records and provide data-driven analyses.
• Troubleshoot issues, identify trends, and improve recovery and quality.
• Create and review SOPs, material specs, protocols, and work instructions.
• Adapt to new projects and challenges.

Skills

Downstream processing

Data analysis

Troubleshooting

Education

BS in biology/chemistry/biochemistry/chemical engineering

MS in biology/chemistry/biochemistry/chemical engineering

PhD not considered

Tools

Unicorn software

JMP

Microsoft Office

Job description

Eli Lilly and Company is expanding its genetic medicines pipeline at the Harborside location in Boston, MA. The Principal Engineer, Downstream Processing will support tech transfer of small-scale purification to manufacturing scale, performing analyses on yield, chromatograms, filtration, and troubleshooting across unit operations.

The role requires deep technical expertise, collaboration with development teams, and the ability to define the downstream technical agenda in the laboratory.