Senior Downstream Bioprocess Engineer – Startup & Scale-Up

Zachary Piper Solutions; Cary (NC); On-site; USD 175,000 - 190,000; Full time

Benefits offered by this job

PTO

Paid holidays

Medical, dental, and vision insurance

Job summary

Zachary Piper Solutions is seeking a Downstream Equipment Engineer to support startup and commissioning of a new commercial-scale biopharmaceutical manufacturing facility. The role provides technical leadership for downstream purification startup, equipment readiness, process validation, technology transfer, and operational excellence.

You will partner with Manufacturing, MSAT, Validation, Quality, and Engineering teams to ensure successful process transfer and commercial readiness, provide

Qualifications

• Bachelor's degree in Chemical Engineering or related field.
• 7+ years of downstream bioprocessing experience in a GMP manufacturing environment.
• Experience with commercial-scale chromatography, filtration, and purification processes.
• Experience supporting facility startup, commissioning, qualification, or process validation activities is highly desirable.
• Strong troubleshooting, communication, and cross-functional collaboration skills.

Responsibilities

• Support qualification, and startup of downstream processing equipment and systems.
• Lead troubleshooting and optimization of chromatography skids and columns.
• Partner with Manufacturing, MSAT, Validation, Quality, and Engineering teams to ensure successful process transfer and commercial readiness.
• Provide on-floor technical support/troubleshooting support during engineering, validation, and commercial manufacturing campaigns.
• Author and review SOPs, batch records, protocols, and technical reports.

Skills

Troubleshooting

Cross-functional collaboration

Process transfer

GMP compliance

Education

Bachelor's degree in Chemical Engineering

Job description

Zachary Piper Solutions is seeking a Downstream Equipment Engineer to support startup and commissioning of a new commercial-scale biopharmaceutical manufacturing facility. The role provides technical leadership for downstream purification startup, equipment readiness, process validation, technology transfer, and operational excellence.

You will partner with Manufacturing, MSAT, Validation, Quality, and Engineering teams to ensure successful process transfer and commercial readiness, provide