Senior DMPK Scientist – PK/PD Strategy & Discovery

Novo Nordisk; Lexington (MA); Vor Ort; USD 140.000 - 190.000; Vollzeit

Benefits dieser Stelle

Company bonus eligibility

Long-term incentive plan

Company vehicles (depending on level)

Comprehensive benefits: medical,Dental

401(k) retirement plan

Paid time off and parental leave

Zusammenfassung

Novo Nordisk in Lexington, MA seeks a Senior Scientist, DMPK to lead discovery DMPK strategy across therapeutic areas, integrating PK/PD modeling and PBPK where needed. You will work cross-functionally with medicinal chemistry, pharmacology, and external CRO partners to advance molecules with drug-like properties.

The role requires a BS/BA with 10+ years (or an advanced degree with 8+ years) and strong ADME expertise; competitive compensation, bonus eligibility, and comprehensive benefits are

Qualifikationen

• BS/BA with 10+ years of relevant experience; or master’s with 8+ years; or PhD with 4+ years.
• Experience in designing and conducting ADME research in pre-clinical or clinical settings.
• Excellent understanding of ADME principles with hands-on PK/PD modeling or biotransformation desirable.
• Strong knowledge of pharmacokinetics and drug metabolism.
• Proficiency in scientific communication and stakeholder engagement.

Aufgaben

• Lead DMPK strategy for discovery programs across multiple therapeutic areas.
• Apply fit-for-purpose in silico models, PK/PD, PBPK to predict human PK and dose.
• Integrate DMPK data with medicinal chemistry and pharmacology to guide design.
• Propose and oversee internal/external research initiatives with study design and data analysis.
• Collaborate with outsourcing managers to manage CRO partners with ADME capabilities.
• Engage with global ADME experts to harmonize methodologies and best practices.
• Communicate DMPK strategy and risk assessments to project teams and management.
• Represent the company externally for publications, conferences, and consortia.
• Maintain awareness of emerging DMPK methods and regulatory expectations.

Kenntnisse

ADME concepts

PK/PD modeling

Pharmacokinetics

Scientific communication

Stakeholder engagement

DMPK domain expertise

Ausbildung

BS/BA with 10+ years

Master's degree with 8+ years

PhD with 4+ years

Jobbeschreibung

Novo Nordisk in Lexington, MA seeks a Senior Scientist, DMPK to lead discovery DMPK strategy across therapeutic areas, integrating PK/PD modeling and PBPK where needed. You will work cross-functionally with medicinal chemistry, pharmacology, and external CRO partners to advance molecules with drug-like properties.

The role requires a BS/BA with 10+ years (or an advanced degree with 8+ years) and strong ADME expertise; competitive compensation, bonus eligibility, and comprehensive benefits are