Senior DMPK & Bioanalytical Lead for Translational PK/PD

Alltrna; Cambridge (MA); On-site; USD 81,000 - 127,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Alltrna is seeking a Senior Research Associate / Associate Scientist, Nonclinical in Cambridge, MA to lead DMPK strategy and oversee bioanalytical work across nonclinical and clinical programs. You will design and interpret PK/PK-PD studies, manage CROs, and contribute to translational biomarker strategies.

The role requires a PhD and 8+ years in DMPK with hands-on data analysis (Phoenix WinNonlin) and experience with LNP delivery concepts.

Qualifications

• PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, or related field.
• 8+ years of industry experience in DMPK or related function.
• Experience overseeing development, qualification, and validation of bioanalytical assays (GLP/GCP) and sample analysis.
• Hands-on PK/PK-PD data analysis and use of Phoenix WinNonlin.
• Experience in translational or clinical biomarker development.
• Strong regulatory writing experience (INDs, study reports).

Responsibilities

• Lead DMPK strategy and oversee bioanalytical work across nonclinical and clinical programs, including PK, biomarker, and translational PD readouts.
• Oversee development, qualification, and validation of bioanalytical assays, and sample analysis with CROs.
• Design, execute, and oversee PK and PK-PD studies of delivery modalities, biodistribution, and biomarker effects.
• Lead PK/PK-PD data analysis across mouse, rat, NHP, and human studies to support dose selection.
• Manage and qualify CRO and external lab partners across bioanalytical and PK programs.
• Support nonclinical toxicology programs in collaboration with internal teams and CROs.
• Analyze, interpret, and present DMPK and translational biomarker data to leadership and stakeholders.
• Author nonclinical sections of regulatory filings (e.g., IND) and briefing documents.
• Serve on the Research Leadership Team; represent DMPK in cross-functional discussions.
• Manage and develop direct report(s); collaborate with pharmacology team.

Skills

DMPK strategy

Bioanalytical oversight

PK/PK-PD analysis

Translational biomarker strategy

Regulatory writing

Education

PhD in pharmacokinetics/pharmacology/biochemistry

Tools

Phoenix WinNonlin

LC-MS/MS

Ligand binding assays

NGS

Job description

Alltrna is seeking a Senior Research Associate / Associate Scientist, Nonclinical in Cambridge, MA to lead DMPK strategy and oversee bioanalytical work across nonclinical and clinical programs. You will design and interpret PK/PK-PD studies, manage CROs, and contribute to translational biomarker strategies.

The role requires a PhD and 8+ years in DMPK with hands-on data analysis (Phoenix WinNonlin) and experience with LNP delivery concepts.