Senior Discovery Chemist — High-Throughput D2B

Otsuka Pharmaceutical Co., Ltd.; Boston (MA); On-site; USD 120,000 - 160,000; Full time

Job summary

Jnana Therapeutics, a wholly owned subsidiary of Otsuka Pharmaceutical, invites a PhD-level Scientist to join our Discovery Chemistry group in Boston. You will support drug discovery programs for hard-to-drug targets using our RAPID chemoproteomics platform, performing high-throughput chemistry and synthesis to interrogate target biology.

You will collaborate with internal teams and external CROs, optimize new reactions, contribute to automation planning, and help prepare patents and

Qualifications

• Ph.D. in Medicinal Chemistry, Organic Chemistry, or closely related field with at least 3 years industry experience in parallel synthesis, liquid handling, high-throughput experimentation and/or direct-to-biology chemistry
• Passion for drug discovery, highly-organized and excellent communication skills

Responsibilities

• Execute direct-to-biology, high-throughput chemistry to support the platform
• Develop and optimize new reactions for direct-to-biology chemistry
• Contribute to establishment of the high-throughput chemistry function and planning/build out of laboratory automation
• Utilize synthetic expertise to design and execute synthesis of target molecules
• Work closely with external chemistry CRO teams to synthesize target molecules
• Work collaboratively across scientific disciplines on multiple projects
• Proactively engage in brainstorming and the generation of new ideas across projects
• Assist in preparing patent applications and publications
• Maintain a safe and productive laboratory environment

Skills

High-throughput experimentation

Direct-to-biology chemistry

Parallel synthesis

Liquid handling

Synthesis planning

Collaborative teamwork

Education

PhD in Medicinal Chemistry or Organic Chemistry

Tools

Laboratory automation

Synthesis execution

External CRO coordination

Job description

Jnana Therapeutics, a wholly owned subsidiary of Otsuka Pharmaceutical, invites a PhD-level Scientist to join our Discovery Chemistry group in Boston. You will support drug discovery programs for hard-to-drug targets using our RAPID chemoproteomics platform, performing high-throughput chemistry and synthesis to interrogate target biology.

You will collaborate with internal teams and external CROs, optimize new reactions, contribute to automation planning, and help prepare patents and