Senior Scientist, High-Throughput Chemistry

Otsuka Pharmaceutical Co., Ltd; Boston (MA); On-site; USD 124,000 - 178,000; Full time

Benefits offered by this job

Medical coverage

Dental coverage

Vision coverage

Life insurance

Disability insurance

Tuition reimbursement

Student loan assistance

401(k) match

Flexible time off

Paid holidays

Paid leave

Job summary

Jnana Therapeutics, a Boston-based subsidiary of Otsuka, is seeking a Scientist for its Discovery Chemistry team to advance drug discovery with direct-to-biology chemistry and high-throughput screening. You will design, synthesize, and optimize small molecules while collaborating across disciplines to interrogate biology and generate drug candidates for challenging targets.

The role emphasizes pioneering chemistry, automation, and patent-focused output, with a competitive US salary range and

Qualifications

• Ph.D. in Medicinal Chemistry, Organic Chemistry, or closely related field with at least 3 years industry experience in parallel synthesis, liquid handling, high-throughput experimentation and/or direct-to-biology chemistry.
• Passion for drug discovery, highly-organized and excellent communication skills.
• Minimum $123,600.00 - Maximum $177,675.00, plus incentive opportunity: The range shown represents a typical pay range... provided to applicants in accordance with states and local laws.

Responsibilities

• Execute direct-to-biology, high-throughput chemistry to support the platform.
• Develop and optimize new reactions for direct-to-biology chemistry.
• Contribute to establishment of the high-throughput chemistry function and planning/build out of laboratory automation.
• Utilize synthetic expertise to design and execute synthesis of target molecules.
• Work closely with external chemistry CRO teams to synthesize target molecules.
• Work collaboratively across scientific disciplines on multiple projects.
• Proactively engage in brainstorming and the generation of new ideas across projects.
• Assist in preparing patent applications and publications.
• Maintain a safe and productive laboratory environment.

Skills

Parallel synthesis

Liquid handling

High-throughput experimentation

Direct-to-biology chemistry

Drug discovery

Communication skills

Education

Ph.D. in Medicinal Chemistry or Organic Chemistry

Job description

About Us

Jnana Therapeutics, a wholly owned subsidiary of Otsuka Pharmaceutical, is a clinical-stage biotechnology company leveraging its next-generation RAPID chemoproteomics platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet needs. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, including rare diseases and immune-mediated diseases. Jnana's lead program, JNT-517, which targets an allosteric site on the phenylalanine transporter SLC6A19, is a potential first-in-class oral approach for the treatment of PKU, a rare genetic metabolic disease. Located in Boston, Jnana brings together scientific leaders in small molecule drug discovery and development, and a highly experienced management team. For more information, please visit www.jnanatx.com and follow us on Twitter/X and LinkedIn. At Jnana, you'll join a diverse, passionate team dedicated to advancing therapies for challenging diseases. Our collaborative, purpose-driven culture fosters innovation, urgency, and belonging-making a great place to work!

About the Opportunity

As a Scientist in our Discovery Chemistry group, you will support our internal chemistry group focused on drug discovery programs for hard-to-drug targets. Through small molecule screening using our novel and proprietary chemoproteomics RAPID platform, our research aims to identify novel small molecules against these challenging targets to interrogate target biology and ultimately to develop drug candidates that can provide clinical value to patients.

Responsibilities

• Execute direct-to-biology, high-throughput chemistry to support the platform
• Develop and optimize new reactions for direct-to-biology chemistry
• Contribute to establishment of the high-throughput chemistry function and planning/build out of laboratory automation
• Utilize synthetic expertise to design and execute synthesis of target molecules
• Work closely with external chemistry CRO teams to synthesize target molecules
• Work collaboratively across scientific disciplines on multiple projects
• Proactively engage in brainstorming and the generation of new ideas across projects
• Assist in preparing patent applications and publications
• Maintain a safe and productive laboratory environment

Desired Qualifications & Past Experience

• Ph.D. in Medicinal Chemistry, Organic Chemistry, or closely related field with at least 3 years industry experience in parallel synthesis, liquid handling, high-throughput experimentation and/or direct-to-biology chemistry
• Passion for drug discovery, highly-organized and excellent communication skills
• Minimum $123,600.00 - Maximum $177,675.00, plus incentive opportunity: The range shown represents a typical pay range or starting pay for individuals who are hired in the role to perform in the United States. Other elements may be used to determine actual pay such as the candidate's job experience, specific skills, and comparison to internal incumbents currently in role. Typically, actual pay will be positioned within the established range, rather than at its minimum or maximum. This information is provided to applicants in accordance with states and local laws.

Application Deadline

This will be posted for a minimum of 5 business days.

Company benefits

• Comprehensive medical, dental, vision, prescription drug coverage, company provided basic life, accidental death & dismemberment, short-term and long-term disability insurance, tuition reimbursement, student loan assistance, a generous 401(k) match, flexible time off, paid holidays, and paid leave programs as well as other company provided benefits.

Come discover more about Jnana and our benefit offerings; https://www.jnanatx.com/join-us/

Disclaimer

This job description is intended to describe the general nature and level of the work being performed by the people assigned to this position. It is not intended to include every job duty and responsibility specific to the position. Jnana Therapeutics reserves the right to amend and change responsibilities to meet business and organizational needs as necessary. Jnana Therapeutics is an equal opportunity employer. All qualified applicants are encouraged to apply and will be given consideration for employment without regard to race, color, sex, gender identity or gender expression, sexual orientation, age, disability, religion, national origin, veteran status, marital status, or any other legally protected characteristic. If you are a qualified individual with a disability or a disabled veteran, you may request a reasonable accommodation, if you are unable or limited in your ability to apply to this job opening as a result of your disability. You can request reasonable accommodations by contacting Accommodation Request.