Associate Director, DMPK and Bioanalysis

Prelude Therapeutics Incorporated; Wilmington (DE); On-site; USD 140,000 - 190,000; Full time

Job summary

Prelude Therapeutics Incorporated is seeking an experienced Associate Director to lead our DMPK and bioanalysis lab. You will manage day-to-day operations, supervise staff, and coordinate CRO studies to deliver timely results on diverse programs including small molecules and ADCs.

You will oversee LC-MS/MS and ELISA workflows, mentor scientists, and drive process improvements across biology and chemistry interfaces to support program needs.

Qualifications

• BS or MS in chemistry, biochemistry, biology, or a related field with 10+ years of experience; or PhD with 5+ years of experience.
• 2+ years supervisory experience in a multidisciplinary environment.
• Practical experience with quantitative LC-MS/MS bioanalysis including method development and troubleshooting.
• Hands-on experience with SCIEX and Waters mass spectrometry platforms.
• Working knowledge of in vitro DMPK assays such as protein binding, microsomal stability, and CYP inhibition.
• Experience calculating and interpreting PK parameters from preclinical studies.
• Strong organization, prioritization, and ability to meet study timelines.
• Clear written and verbal communication across scientific functions.

Responsibilities

• Manage daily operation, workload, and priorities of the DMPK and bioanalysis lab.
• Oversee LC-MS/MS analysis of in vitro assays and data interpretation.
• Oversee bioanalysis of preclinical PK samples including LC-MS/MS or ELISA analyses.
• Ensure clear, accurate, and timely delivery of study results.
• Coordinate outsourced in vitro and in vivo studies with CROs across regions.
• Maintain laboratory upkeep and troubleshoot LC-MS instruments.
• Collaborate with biology and chemistry teams to align work with programs.
• Train, mentor, and manage laboratory staff for growth and performance.
• Identify opportunities to improve workflows, data quality, and turnaround time.

Skills

DMPK expertise

Bioanalysis

LC-MS/MS data interpretation

Staff mentoring

Cross-functional collaboration

Project management

Data analysis

Communication skills

Education

BS or MS in chemistry/biochemistry/biology

PhD in a related field (optional)

Tools

SCIEX mass spectrometry

Waters mass spectrometry

LC-MS/MS instrumentation

Job description

Description

We are seeking an experienced, hands-on Associate Director to lead the day-to-day operations of our DMPK and bioanalysis laboratory. This role oversees in-house screening and bioanalytical work, coordinates outsourced studies with contract research organizations (CROs), and ensures the timely delivery of study results across our diverse portfolio spanning small molecules, targeted protein degraders, and ADCs. The Associate Director will also manage, train, and mentor staff, and collaborate with colleagues in biology and chemistry teams.

Key responsibilities

• Manage the daily operation, workload, and priorities of the DMPK and bioanalysis laboratory.
• Oversee the conduct and analysis, by LC-MS/MS, of vitro assays such as plasma protein binding, microsomal stability, and CYP inhibition including data processing and interpretation.
• Oversee bioanalysis of preclinical pharmacokinetic (PK) samples for small and large molecules, including sample processing, analysis by LC-MS/MS or ELISA, and PK data processing and interpretation.
• Ensure the clear, accurate, and timely delivery of study results.
• Coordinate outsourced in vitro and in vivo studies with domestic and international CROs, from study planning and initiation through data review and reporting.
• Manage laboratory upkeep, troubleshoot instrument issues and coordinate routine maintenance for LC-MS
• Collaborate with biology and chemistry teams to align DMPK and bioanalytical work with program needs.
• Train, mentor, and directly manage laboratory staff, supporting their technical growth, scientific judgment, and professional development.
• Identify opportunities to improve laboratory workflows, data quality, turnaround time, and consistency.

Requirements

Qualifications

• BS or MS in chemistry, biochemistry, biology, or a related field, with 10+ years of relevant experience; or PhD in a relevant field, with 5+ years of relevant experience.
• 2+ years related supervisory experience in a multidisciplinary environment with demonstrated ability to manage, train, or mentor scientists or laboratory staff.
• Practical experience with quantitative LC-MS/MS bioanalysis, including method development/optimization, sample analysis, data review, and troubleshooting.
• Hands-on experience with SCIEX and Waters mass spectrometry and liquid chromatography platforms
• Working knowledge of in vitro DMPK assays such as protein binding, microsomal stability, and CYP inhibition.
• Experience calculating, reviewing, and interpreting PK parameters from preclinical studies.
• Strong organization and follow-through, with the ability to manage competing priorities to meet study timelines.
• Clear written and verbal communication skills and the ability to work effectively across scientific functions.

Preferred qualifications

• Experience supporting multiple drug modalities, such as small molecules, targeted protein degraders, and ADCs.
• Familiarity with bioanalytical approaches used for biologics and ADCs, such as ligand-binding assays or modality-specific analytical methods.
• Experience coordinating external CRO studies and reviewing their data and reports.