Senior Director, Translational & Clinical Biomarkers

DoveTree Medicines; Cambridge (MA); Vor Ort; USD 230.000 - 320.000; Vollzeit

Zusammenfassung

DoveTree Medicines seeks an experienced Director/Senior Director of Translational & Biomarker to lead biomarker strategy across discovery and development programs at our Cambridge, MA site. You will drive target engagement, pharmacodynamic readouts, and patient stratification to inform molecule advancement and clinical decisions.

You will partner with cross-functional teams to integrate biomarkers into early and late development, guide assay strategy, and oversee external CROs and collaborators,

Qualifikationen

• PhD, MD, PharmD, or equivalent advanced degree in oncology, molecular biology, translational medicine, immunology, pathology, or related discipline.
• 8+ years (Director) or 12+ years (Senior Director) of biotechnology or pharmaceutical industry experience.
• Demonstrated experience supporting oncology drug discovery and development programs through IND-enabling stages, early and late clinical development.
• Deep understanding of translational science, oncology biomarkers, precision medicine, and clinical biomarker development.
• Experience developing and implementing biomarker strategies in early clinical development.
• Familiarity with tissue- and blood-based biomarker platforms, including genomics, proteomics, ctDNA, IHC, flow cytometry, or related technologies.
• Strong understanding of biomarker regulatory considerations and clinical trial integration.
• Experience managing external CROs, laboratory partners, and scientific collaborations.
• Excellent communication, presentation, and cross-functional leadership skills.
• Demonstrated ability to influence strategy and decision-making in a matrixed environment.
• Comfortable operating in a fast-paced, entrepreneurial biotech environment.

Aufgaben

• Lead translational and clinical biomarker strategy across discovery and development programs.
• Develop and implement biomarker plans to support target engagement, mechanism of action, pharmacodynamic response, patient stratification, and resistance monitoring.
• Guide biomarker integration into preclinical and clinical development strategies by identifying and validating predictive and pharmacodynamic biomarkers.
• Drive translational approaches that link preclinical findings to clinical hypotheses and development decisions.
• Contribute to indication selection, patient enrichment, and precision medicine strategies.
• Partner closely with clinical development, regulatory and biostatistics teams to integrate biomarkers into clinical trials.
• Support design and implementation of biomarker components of early clinical studies, including first-in-human and proof-of-concept trials.
• Oversee biomarker assay strategy, sample management, data generation, and interpretation across clinical studies.
• Contribute to clinical protocol development, biomarker analysis plans, and translational study design.
• Interpret and communicate complex biomarker and translational datasets to cross-functional teams and senior leadership.
• Identify translational risks and opportunities to support efficient clinical development progression.
• Provide strategic oversight of biomarker assay development, validation, and implementation using tissue-, blood-, and molecular-based platforms.
• Manage external CROs, laboratory partners, academic collaborators, and technology providers supporting biomarker activities.
• Ensure high-quality execution, timelines, budgets, and deliverables across external collaborations.
• Stay current with emerging technologies, regulatory and scientific advances in translational oncology, biomarker science, and precision medicine.
• Contribute to development of scalable biomarker and translational infrastructure and best practices as the company grows.
• Contribute to regulatory submissions and interactions related to biomarker and translational strategies.
• Support translational and biomarker sections of INDs, briefing documents, study reports, and regulatory responses.
• Provide strategic input into portfolio prioritization, clinical development planning, and overall R&D strategy.
• Serve as a scientific thought partner to executive leadership and cross-functional program teams.

Jobbeschreibung

DoveTree Medicines seeks an experienced Director/Senior Director of Translational & Biomarker to lead biomarker strategy across discovery and development programs at our Cambridge, MA site. You will drive target engagement, pharmacodynamic readouts, and patient stratification to inform molecule advancement and clinical decisions.

You will partner with cross-functional teams to integrate biomarkers into early and late development, guide assay strategy, and oversee external CROs and collaborators,