Senior Director, Small Molecule Portfolio Strategy

Amgen; South San Francisco (CA); On-site; USD 210,000 - 284,000; Full time

Benefits offered by this job

Competitive benefits

Flexible work models

Job summary

Amgen Inc. in South San Francisco, CA, is seeking a Director of PKDM-BA for Small Molecule Portfolio Strategy & Leadership to guide discovery through clinical development and regulatory submission.

You will lead cross-functional teams, shape portfolio strategy, and drive scientific and translational plans, with a focus on optimizing drug disposition and development outcomes. The role requires deep PK/PD expertise, proven leadership, and strong collaboration across functions to advance Amgen’s

Qualifications

• PhD, PharmD or MD with 5+ years of industry experience in Pharmaceutical Sciences, Pharmacokinetics, Drug Metabolism, Pharmacology, Chemistry, or a related discipline.
• Alternatively, a Master’s degree with 8+ years of industry experience in the same fields.
• Or a Bachelor’s degree with 10+ years of industry experience in the same fields.
• Proven track record in leadership across small molecule discovery and development.
• Experience supporting regulatory submissions (INDs, NDAs).
• Strong PK/PD and translational strategies expertise.

Responsibilities

• Provide strategic PKDM-BA leadership for small molecule discovery and development programs.
• Drive cross-functional project teams through scientific innovation and risk assessment.
• Lead PKDM-BA contributions to regulatory submissions (INDs, NDAs) and regulatory interactions.
• Define and execute scientific strategies for candidate selection, optimization, development, and registration.
• Identify and implement emerging technologies to improve development outcomes.
• Partner with business development to assess external opportunities and perform due diligence.
• Build collaborative relationships across therapeutic areas and partner functions.
• Recruit, develop, and mentor scientific talent.
• Contribute to organizational strategy for PKDM-BA capabilities at Amgen.

Skills

Scientific leadership

Cross-functional collaboration

Strategic planning

Regulatory submissions

Education

PhD/PharmD/MD + 5+ years

Master +8 years

Bachelor +10 years

Job description

Amgen Inc. in South San Francisco, CA, is seeking a Director of PKDM-BA for Small Molecule Portfolio Strategy & Leadership to guide discovery through clinical development and regulatory submission.

You will lead cross-functional teams, shape portfolio strategy, and drive scientific and translational plans, with a focus on optimizing drug disposition and development outcomes. The role requires deep PK/PD expertise, proven leadership, and strong collaboration across functions to advance Amgen’s