Senior Director, Medical Affairs Operations — Remote

Amylyx Pharmaceuticals, Inc.; Cambridge (MA); Hybrid; USD 281,000 - 316,000; Full time

Job summary

Amylyx Pharmaceuticals, Inc. in Cambridge, MA is seeking a Senior Director of Medical Affairs Operations to lead the operational backbone of Medical Affairs. You will build scalable processes, governance, budgets and vendor management to support launch readiness and compliant execution.

In this high-impact role you will partner across functions, develop KPIs and dashboards, oversee evidence generation, and shape a high-performing medical organization in a fast-paced biotechnology environment.

Qualifications

• 10+ years in Medical Affairs Operations or related leadership roles in biotech/pharma.
• Experience building scalable operational infrastructure and budgets.
• Proven ability to influence senior stakeholders in a matrixed org.

Responsibilities

• Lead strategic operations for Medical Affairs to enable launch readiness.
• Oversee budgets, forecasting, accruals, and vendor governance.
• Develop KPIs, dashboards, and analytics for Medical Affairs.
• Manage evidence generation activities and investigator-initiated research.
• Collaborate with cross-functional partners across Commercial, Regulatory, and Clinical.
• Build and scale the Medical Affairs Operations team and processes.

Skills

Leadership

Project management

Vendor management

Budget management

Medical affairs operations

Cross-functional collaboration

Launch planning

KOL engagement

Compliance knowledge

Education

Bachelor's degree

MBA/PhD preferred

Tools

CRM platform

Job description

Amylyx Pharmaceuticals, Inc. in Cambridge, MA is seeking a Senior Director of Medical Affairs Operations to lead the operational backbone of Medical Affairs. You will build scalable processes, governance, budgets and vendor management to support launch readiness and compliant execution.

In this high-impact role you will partner across functions, develop KPIs and dashboards, oversee evidence generation, and shape a high-performing medical organization in a fast-paced biotechnology environment.