Senior Director, Immunology Translational Research (Hybrid)

BioSpace; Waltham (MA); Híbrido; USD 338.000 - 390.000; Jornada completa

Descripción de la vacante

CSL Behring, a global biotherapeutics leader, seeks a Senior Director of Immunology Translational & Clinical Research to shape early clinical development in MA or Melbourne. This hybrid role requires close collaboration with discovery, translational medicine, and BD teams to advance immunology programs from ideation to first‑in‑disease.

The successful candidate will translate mechanistic data into clinical hypotheses, lead cross‑functional teams, and influence portfolio prioritization while

Formación

• MD or DO with clinical experience in rheumatology (preferred); neuroimmunology and/or dermatology also acceptable
• Demonstrated bench‑to‑bedside research mindset with hands‑on, working‑level experience translating preclinical and translational science into clinical strategy, not purely oversight experience
• Experience in drug development within a biotech, pharmaceutical, or academic environment
• Demonstrated hands‑on experience in preclinical to first‑in‑disease (or equivalent early clinical milestone) programs in immunology
• Deep scientific expertise in the immunological mechanisms underpinning autoimmune and inflammatory diseases
• Established and active network in drug development with recognized relationships across rheumatology, neuroimmunology, and/or dermatology communities
• Proven track record of evaluation of preclinical and clinical assets, including direct target assessment, data package review, and go/no‑go decision‑making, plus active support of BD due diligence and TPP drafting
• Strong ability to synthesize complex scientific data and communicate strategy clearly to diverse audiences including senior leadership

Responsabilidades

• Act as the hands‑on clinical subject matter expert and internal champion for one or more immunology disease areas, with rheumatology expertise strongly preferred; neuroimmunology and/or dermatology also considered
• Bring a bench‑to‑bedside mindset, working directly with bench scientists to translate mechanistic understanding of immune pathology into actionable therapeutic hypotheses and target identification strategies
• Sit alongside the research team as an active partner in prioritizing therapeutic targets and building out clinical development plans, not just reviewing decisions after the fact
• Stay personally close to the competitive landscape, emerging science, and unmet medical need across assigned disease areas, digging into primary data and literature directly
• Represent CSL Behring at key scientific conferences, advisory boards, and KOL meetings; build and actively maintain a hands‑on network of thought leaders, clinical investigators, and academic collaborators
• Get directly involved end-to-end in asset progression from ideation through first‑in‑disease designation, personally working through scientific rationale, translational endpoints, patient population selection, and clinical strategy alongside the project team
• Lead or co‑lead target and asset evaluation activities, personally reviewing preclinical and clinical data packages, mechanism‑of‑action assessments, and translational feasibility analyses line by line
• Partner with development colleagues on IND‑enabling studies, proof‑of‑concept study designs, and Phase 1/1b protocol development, working directly with study teams
• Be the go‑to immunology clinical subject matter expert embedded with discovery colleagues day‑to‑day, bridging preclinical science and clinical relevance to directly shape program design and go/no‑go decisions
• Work hands‑on with discovery and translational teams to define disease‑relevant biomarkers, pharmacodynamic readouts, and patient stratification strategies for early clinical programs
• Actively contribute to R&D programs as a working subject matter expert, providing direct, in‑the‑weeds guidance on the clinical development pathway
• Partner closely and continuously with the Research Therapeutic Area Lead, RPLs, and Immunology core team members to prioritize therapeutic targets and personally help maintain a best‑in‑class immunology portfolio
• Partner directly with Business Development colleagues on in‑licensing, and partnering opportunities within immunology, on clinical and scientific due diligence
• Contribute to drafting Target Product Profiles (TPPs), integrated development plans, and portfolio reviews in partnership with clinical, commercial, and research colleagues
• Provide disease area expertise to regulatory submissions, clinical study reports, and scientific communications

Conocimientos

Bench-to-bedside mindset

Senior leadership communication

Immunology drug development

KOL engagement

Cross-functional collaboration

Educación

MD/DO with rheumatology clinical experience

Descripción del empleo

CSL Behring, a global biotherapeutics leader, seeks a Senior Director of Immunology Translational & Clinical Research to shape early clinical development in MA or Melbourne. This hybrid role requires close collaboration with discovery, translational medicine, and BD teams to advance immunology programs from ideation to first‑in‑disease.

The successful candidate will translate mechanistic data into clinical hypotheses, lead cross‑functional teams, and influence portfolio prioritization while