Senior Digital Lab Automation Engineer

BioSpace

Norwood (MA)

On-site

USD 146,000 - 234,000

Full time

14 days+

Application generator

Don’t send a generic resume — generate a resume and cover letter tailored to this exact role.

Get past ATS filters

Benefits offered by this job

Competitive healthcare

Well-being resources

Family planning benefits

Generous paid time off

Savings and investments

Location-specific perks

Job summary

Moderna seeks a Principal Systems Engineer, Digital Lab Systems to support delivery and administration of laboratory systems, including configuration, deployment, test protocol execution, and user training.

You will lead automation across QC labs, design automated workflows with Hamilton systems, and drive data integration with LIMS and enterprise apps while ensuring GLP/GCLP compliance and lifecycle management.

Qualifications

Bachelor’s or Master’s degree in engineering, Computer Science, Biotechnology, Robotics, or related field.
8+ years of experience in laboratory automation or robotics.
Experience with liquid handling systems and automation platforms.
Experience integrating systems using APIs (REST or similar), databases, or middleware technologies.
Programming experience in Python, Java, C++, or similar.
Experience with data structures, database design, and LIMS integration.
Exposure to AI/ML applications in laboratory or automation workflows.
Experience with Hamilton platforms (VENUS, BiOS).
Familiarity with web services (REST/SOAP) and distributed systems.
Experience in regulated environments (GCP, GLP, ISO standards).
Knowledge of version control (Git) and Agile methodologies.
Strong troubleshooting and communication skills.

Responsibilities

Serve as a technical leader for laboratory automation within the QC Laboratory, supporting and expanding automation capabilities across testing and sample management operations.
Design, develop, implement, and optimize automated workflows for QC assays utilizing Hamilton technologies and VENUS software.
Lead deployment of integrated automation solutions and dynamic scheduling platforms.
Translate manual workflows into scalable automated systems to improve efficiency and consistency.
Act as SME for complex automation troubleshooting, root cause analysis, and issue resolution.
Develop and implement data integration between laboratory instruments, automation systems, LIMS, and enterprise apps.
Design, build, and maintain data structures, pipelines, and workflow architectures.
Develop and support system integrations using REST APIs, web services, middleware, and connected lab architectures.
Contribute to AI-enabled and ML-driven workflows and decision-support capabilities.
Provide leadership and support for automated workcell platforms like Hamilton CTUs.
Ensure operational readiness, reliability, maintenance, and performance of automated storage and biobanking systems.
Support commissioning, qualification, validation, and lifecycle management for automation platforms.
Drive improvements in sample tracking, inventory control, and end-to-end processes.
Serve as system owner for critical automation platforms, ensuring reliability and continuous improvement.
Evaluate and implement new automation tech and digital capabilities.
Lead investigations into deviations and performance gaps with CAPA actions.
Maintain documentation and configurations per SOPs and quality standards.
Ensure automation systems comply with GLP and GCLP requirements.
Interface with vendors to support implementation, optimization, upgrades, and long-term strategy.
Mentor junior engineers and provide guidance on automation initiatives.
Deliver training and knowledge transfer to lab personnel.