Lead Lab Automation Systems Engineer

Moderna Therapeutics; Norwood (MA); On-site; USD 146,000 - 234,000; Full time

Job summary

Moderna Therapeutics is seeking a Principal Systems Engineer, Digital Lab Systems to lead automation initiatives in the QC Laboratory. You will design and deploy automated workflows, integrate data across instruments and LIMS, and mentor junior engineers.

The role requires 8+ years in laboratory automation, expertise with Hamilton platforms, and strong programming skills (Python/Java/C++). Regulatory experience and excellent troubleshooting are essential for success.

Qualifications

• Bachelor’s or master’s degree in engineering, CS, biotech, robotics, or related field.
• 8+ years of experience in laboratory automation or robotics.
• Experience with liquid handling systems and automation platforms.
• Experience integrating systems using APIs (REST) or middleware technologies.
• Programming experience in Python, Java, C++, or similar.
• Experience with data structures, database design, and LIMS integration.
• Exposure to AI/ML applications in laboratory or automation workflows.
• Experience with Hamilton platforms (VENUS, BiOS).
• Familiarity with web services (REST/SOAP) and distributed systems.
• Experience in regulated environments (GxP, GLP, ISO).
• Knowledge of version control (Git) and Agile methodologies.
• Strong troubleshooting and communication skills.

Responsibilities

• Serve as a technical leader for laboratory automation within the QC Laboratory.
• Design, develop, implement, and optimize automated workflows for QC assays using Hamilton platforms.
• Lead deployment of integrated automation solutions and dynamic scheduling platforms.
• Translate manual workflows into high-throughput automated systems for efficiency and consistency.
• Act as SME for automation troubleshooting and root cause analysis.
• Develop data integration between instruments, automation systems, LIMS, and enterprise apps.
• Build data structures, data pipelines, and workflow architectures for automation.
• Develop and support system integrations using REST APIs and middleware.
• Contribute to AI-enabled and ML-driven laboratory workflows and decision-support.
• Provide leadership and support for automated workcell platforms like Hamilton CTUs.
• Ensure operational readiness and maintenance of automation systems.
• Support commissioning, qualification, validation, and lifecycle activities.
• Drive improvements in sample tracking, storage, and end-to-end processes.
• Interface with vendors for implementation and upgrades.
• Mentor engineers and deliver training on platforms and best practices.

Skills

Python

Java

C++

REST APIs

LIMS integration

AI/ML exposure

Hamilton VENUS

Git

Agile methodologies

Troubleshooting

Education

Bachelor's or Master's degree

Tools

Hamilton VENUS

Job description

Moderna Therapeutics is seeking a Principal Systems Engineer, Digital Lab Systems to lead automation initiatives in the QC Laboratory. You will design and deploy automated workflows, integrate data across instruments and LIMS, and mentor junior engineers.

The role requires 8+ years in laboratory automation, expertise with Hamilton platforms, and strong programming skills (Python/Java/C++). Regulatory experience and excellent troubleshooting are essential for success.