Senior Data Platform Architect - AWS & Genomics

Vesalius Therapeutics; Cambridge (MA); On-site; USD 179,000 - 236,000; Full time

Job summary

Vesalius Therapeutics is seeking a Principal Data Engineer to lead the architecture of our data platform supporting human genetics, multi-omics, and high-content imaging research in Cambridge, MA. You will define the roadmap for cloud data engineering, orchestration, warehousing, and access layers, with broad technical authority and a hands-on leadership style.

Join a fast-growing biotech team modernizing infrastructure to enable genotype-driven discoveries and scalable data science

Qualifications

• 10+ years building and operating production data infrastructure.
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• Deep AWS expertise: S3, IAM, EC2, Batch, Lambda, Spark.
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• Strong Python and SQL, with production-grade pipelines.
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• Experience with workflow orchestration tools and selecting among them.
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• Infrastructure as code, CI/CD, containers, and observability are core.
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• Data modelling and warehouse/lakehouse design with metadata tracing.
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• Cost governance at scale across large data assets.
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• Fluency with scientific data semantics and collaboration with scientists.
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Responsibilities

• Serve as technical owner and architect of our AWS environment and data platform.
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• Lead cost governance, budgeting, tagging, rightsizing, and lifecycle management.
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• Define developer operations for data platforms, including IaC and CI/CD.
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• Upgrade data lake, orchestration, metadata, and data ingestion workflows.
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• Collaborate with ML and computational biology leaders to align platform with modelling needs.

Skills

10+ years data infra

AWS expertise

Python & SQL

Workflow orchestration

Infrastructure as code

CI/CD

Data modelling

Cost governance

Scientific data semantics

Tools

Nextflow

Airflow

Temporal

Step Functions

Redun

CloudFormation/CDK

Spark/EMR

Databricks

OpenMetadata

Snowflake

SageMaker

MLflow/Weights & Biases

Job description

Vesalius Therapeutics is seeking a Principal Data Engineer to lead the architecture of our data platform supporting human genetics, multi-omics, and high-content imaging research in Cambridge, MA. You will define the roadmap for cloud data engineering, orchestration, warehousing, and access layers, with broad technical authority and a hands-on leadership style.

Join a fast-growing biotech team modernizing infrastructure to enable genotype-driven discoveries and scalable data science