Senior Computational Biologist, Neurodegeneration & AI Imaging

Alector Inc.; South San Francisco (CA); Hybrid; USD 130,000 - 190,000; Full time

Benefits offered by this job

Restaurant d'entreprise

Indemnités de stage/alternance

Job summary

Alector is seeking a Senior Associate Scientist, Computational Biology, to join our dynamic team. You will play a key role in advancing our understanding of the biology underlying neurodegenerative diseases, improving our computational pipelines, and supporting the discovery of new therapeutic targets.

In this role, you will analyze and interpret complex biological data, with a particular focus on high-content imaging and cell segmentation, alongside high-dimensional multi-omics datasets.

Qualifications

• MS with at least three years of relevant experience or PhD with at least one year in biotechnology, computational biology, data science, bioinformatics, or a related field.
• Hands-on experience analyzing high-content imaging data, including cell segmentation, feature extraction, and high-dimensional datasets (bulk or single-cell RNA-seq or proteomics).
• Experience applying deep-learning/AI methods to image analysis, especially cell segmentation (Cellpose, MEDIAR).
• Proficiency in R and Python, with DESeq2, Seurat, Scanpy, dplyr, and tidyverse.
• Familiarity with shell scripting, Git, and AWS/cloud computing environments.
• Fundamental biology understanding and ability to apply computational approaches to biological questions.
• Excellent written and verbal communication skills for technical and nontechnical audiences.

Responsibilities

• Advance image-based research by developing segmentation, feature extraction, and single-cell tracking analyses across diverse samples.
• Modernize pipelines by evaluating AI/ML tools to improve automation and throughput.
• Turn imaging and multi-omics data into actionable biological insights in collaboration with R&D.
• Develop interactive data-exploration portals for internal use and ensure data accessibility.
• Create reproducible workflows with code and data management best practices, including version control.
• Present analytical results clearly to cross-functional teams.

Skills

High-content imaging

Cell segmentation

Deep learning

R

Python

DESeq2

Seurat

Scanpy

AWS

Education

MS with 3+ years in biotech/comp bio/data science/bioinformatics

PhD with 1+ year in related field

Tools

Cellpose

MEDIAR

TensorFlow

PyTorch

Shiny

Dash

Job description

Alector is seeking a Senior Associate Scientist, Computational Biology, to join our dynamic team. You will play a key role in advancing our understanding of the biology underlying neurodegenerative diseases, improving our computational pipelines, and supporting the discovery of new therapeutic targets.

In this role, you will analyze and interpret complex biological data, with a particular focus on high-content imaging and cell segmentation, alongside high-dimensional multi-omics datasets.