Senior Bioprocess Downstream Engineer — Scale & Transfer

Moderna Therapeutics; Norwood (MA); On-site; USD 131,000 - 209,000; Full time

Benefits offered by this job

Competitive healthcare benefits

Well-being resources

Generous paid time off

Job summary

Moderna Therapeutics is seeking an experienced Process Development Engineer to join the Clinical Process and Product Development team at the Norwood, MA site. The role focuses on downstream process development for recombinant enzymes produced in E.

coli, with responsibilities spanning design, optimization, scale-up, and technology transfer. You will lead laboratory studies, define process flows and control strategies, and apply DOE, multivariate analysis, and data trends to guide decisions.

Qualifications

• PhD or MS/BS with required years of industry experience as stated in the job description.
• Experience developing downstream processes for recombinant proteins/enzymes across multiple unit operations.
• Hands-on experience designing, executing, analyzing, and interpreting complex process-development experiments.

Responsibilities

• Lead development and implementation of moderately complex process and product development initiatives with cross-functional CMC partners.
• Design, execute, analyze, and document lab studies to develop robust downstream processes.
• Develop and optimize integrated process trains using unit operations like lysis, clarification, filtration, chromatography, and ultrafiltration/diafiltration.

Skills

Process development

Statistical analysis

Experiment design

Cross-functional collaboration

Communication

Mentoring

Education

PhD in Chemical Eng/ Biochemical Eng/ Bioprocess Eng

MS with 8+ years relevant industry experience

BS/BA with 10+ years relevant industry experience

Tools

JMP

Multivariate analysis

Job description

Moderna Therapeutics is seeking an experienced Process Development Engineer to join the Clinical Process and Product Development team at the Norwood, MA site. The role focuses on downstream process development for recombinant enzymes produced in E.

coli, with responsibilities spanning design, optimization, scale-up, and technology transfer. You will lead laboratory studies, define process flows and control strategies, and apply DOE, multivariate analysis, and data trends to guide decisions.