Senior Biophysics Scientist, Small Molecule Drug Discovery

Beacon Hill Staffing Group; South San Francisco (CA); On-site; USD 130,000 - 190,000; Full time

Job summary

Beacon Hill Staffing Group is seeking a talented biophysicist to join our Lead Discovery team in South San Francisco, CA. The role focuses on biophysical and mechanistic characterization of small-molecule ligands with protein targets, contributing to SAR and hit-to-lead efforts in a highly collaborative environment.

The ideal candidate has a PhD in biophysics/biochemistry with 3+ years in industry or academia, expertise in SPR (Biacore S200/8K+), and experience with other biophysical methods,

Qualifications

• PhD in biophysics, biochemistry, or related discipline.
• 3+ years of industry or relevant academic experience in small-molecule drug discovery biophysics.
• Demonstrated expertise in designing, developing, and interpreting biophysical characterization of small molecule-protein interactions by SPR.
• Strong background in other biophysical techniques such as TSA, DLS, Spectral Shift, NMR, or ITC.

Responsibilities

• Independently ideate and implement binding characterization studies of small molecules and proteins by SPR (Biacore S200 and 8K+).
• Perform routine compound screening and advanced mechanistic studies using diverse biophysical assays (nanoDSF, DLS, Spectral Shift, etc.).
• Coordinate and manage externalized biophysical studies to CRO partners.
• Maintain detailed experimental records, analyze and interpret data to drive SAR and advance hit-to-lead/lead optimization across projects.
• Communicate results at internal meetings and standard study reports.

Skills

Biophysics expertise

SPR binding studies

Data analysis

Scientific communication

Project planning

Cross‑team collaboration

Education

PhD in biophysics/biochemistry

Tools

Biacore SPR

Graphing/statistics software

Job description

Beacon Hill Staffing Group is seeking a talented biophysicist to join our Lead Discovery team in South San Francisco, CA. The role focuses on biophysical and mechanistic characterization of small-molecule ligands with protein targets, contributing to SAR and hit-to-lead efforts in a highly collaborative environment.

The ideal candidate has a PhD in biophysics/biochemistry with 3+ years in industry or academia, expertise in SPR (Biacore S200/8K+), and experience with other biophysical methods,