Sr. Research Scientist Biophysics

Beacon Hill Staffing Group; South San Francisco (CA); Sur place; USD 130 000 - 190 000; Plein temps

Résumé du poste

Beacon Hill Staffing Group is seeking a talented biophysicist to join our Lead Discovery team in South San Francisco, CA. The role focuses on biophysical and mechanistic characterization of small-molecule ligands with protein targets, contributing to SAR and hit-to-lead efforts in a highly collaborative environment.

The ideal candidate has a PhD in biophysics/biochemistry with 3+ years in industry or academia, expertise in SPR (Biacore S200/8K+), and experience with other biophysical methods,

Qualifications

• PhD in biophysics, biochemistry, or related discipline.
• 3+ years of industry or relevant academic experience in small-molecule drug discovery biophysics.
• Demonstrated expertise in designing, developing, and interpreting biophysical characterization of small molecule-protein interactions by SPR.
• Strong background in other biophysical techniques such as TSA, DLS, Spectral Shift, NMR, or ITC.

Responsabilités

• Independently ideate and implement binding characterization studies of small molecules and proteins by SPR (Biacore S200 and 8K+).
• Perform routine compound screening and advanced mechanistic studies using diverse biophysical assays (nanoDSF, DLS, Spectral Shift, etc.).
• Coordinate and manage externalized biophysical studies to CRO partners.
• Maintain detailed experimental records, analyze and interpret data to drive SAR and advance hit-to-lead/lead optimization across projects.
• Communicate results at internal meetings and standard study reports.

Connaissances

Biophysics expertise

SPR binding studies

Data analysis

Scientific communication

Project planning

Cross‑team collaboration

Formation

PhD in biophysics/biochemistry

Outils

Biacore SPR

Graphing/statistics software

Description du poste

We are seeking a talented and highly motivated biophysicist with relevant experience in small-molecule drug discovery to join our team. The successful candidate will be a member of an established and highly collaborative Lead Discovery group that includes teams within Biophysics, Bioassays, Structure Biology, Protein Sciences, and Compound Management. The scientist will be responsible for the biophysical and mechanistic characterization of small-molecule ligands binding to protein targets. The successful candidate will be able to integrate biophysical knowledge with the goal of supporting routine compound profiling as well as understanding the molecular mechanism of action to advance the drug discovery pipeline. This is primarily a hands-on laboratory position based in our South San Francisco, CA, research site, reporting to the Principal Research Scientist, Biophysics.

Job Description

What you’ll do:

• Independently ideate and implement binding characterization studies of small molecules and proteins by SPR (Biacore S200 and 8K+).
• Perform routine compound screening and advanced mechanistic studies using an array of biophysical assays (nanoDSF, DLS, Spectral Shift, etc.).
• Coordinate and manage externalized biophysical studies to CRO partners.
• Maintain detailed experimental records, analyze and interpret data to drive SAR and advance hit-to-lead/lead optimization activities in diverse projects.
• Communicate results at internal meetings and industry-standard study reports.
• Perform all duties in keeping with the Company’s core values, policies and all applicable regulations.

Requirements

• PhD in biophysics, biochemistry, or related discipline.
• 3+ years of industry or relevant academic experience in the field of small molecule drug discovery biophysics.
• Demonstrated expertise in designing, developing, and interpreting biophysical characterization of small molecule-protein interactions by SPR.
• Strong theoretical and technical background in other biophysical technologies such as TSA, DLS, Spectral Shift, NMR, or ITC.
• Experience with graphing/statistics software is a plus.
• Strong troubleshooting, organization, and planning skills.
• Excellent oral and written communication skills.

Attributes

• Ability to thrive in a fast-paced, dynamic small company environment.
• Critical thinker with a demonstrated ability to collaborate effectively across teams and functional areas.
• Capacity to synthesize and integrate complex ideas and to clearly communicate key insights.
• Skilled at identifying and solving problems early, planning, and risk mitigation.
• Curiosity, passion, and desire to make a difference.
• Contribute to our company culture, sense of team, and collaborative spirit.