Senior Scientist Molecular Interactions for Biologics

Merck & Co.; South San Francisco (CA); On-site; USD 131,000 - 207,000; Full time

Job summary

Merck & Co. in South San Francisco, CA, seeks a motivated scientist to join the Molecular Interactions group in Discovery Biologics.

You will design and execute binding and kinetics studies to guide biologics discovery, generate high-quality data, and support candidate selection. Collaborating with antibody discovery, protein sciences, and computational biology teams, you will optimize assays, apply SPR, Carterra, BLI, and flow cytometry, and help develop scalable workflows.

Qualifications

• PhD or equivalent with relevant discovery experience.
• A proven track record designing and interpreting complex binding studies.
• Experience with protein interactions and quantitative assay development.

Responsibilities

• Design, execute, troubleshoot, and interpret molecular interaction studies guiding program direction.
• Generate high-quality binding, kinetics, and epitope data to support candidate selection.
• Collaborate with multidisciplinary teams to define assays and communicate findings clearly.

Skills

Antibodies discovery

Biomolecular interactions

Functional assays

Kinetic studies

Protein characterization

Protein interactions

Quantitative assay

Surface Plasmon Resonance (SPR)

Binding affinity

Education

Bachelor's degree in biological sciences

Master's degree in biological sciences

Ph.D. in biological sciences

Tools

Surface Plasmon Resonance (SPR)

Carterra

Biacore

Biolayer Interferometry

KinExA

Job description

Merck & Co. in South San Francisco, CA, seeks a motivated scientist to join the Molecular Interactions group in Discovery Biologics.

You will design and execute binding and kinetics studies to guide biologics discovery, generate high-quality data, and support candidate selection. Collaborating with antibody discovery, protein sciences, and computational biology teams, you will optimize assays, apply SPR, Carterra, BLI, and flow cytometry, and help develop scalable workflows.