Senior Bioinformatics Scientist – Oncology Diagnostics

Yoh,-A-Day-; Sunnyvale (CA); Hybrid; USD 175,000 - 205,000; Full time

Benefits offered by this job

Medical benefits

401K Retirement Plan

Career development programs

Life & Disability Insurance

Job summary

Yoh is seeking a Senior Bioinformatics Scientist in Sunnyvale, CA, to lead hands-on development, optimization, and validation of computational workflows for a next-generation oncology diagnostic platform. The role combines bioinformatics, NGS, statistics, and assay development within a cross-functional team.

The ideal candidate will transform sequencing data into reliable outputs, improve detection of low-frequency signals, and establish scalable, regulatory-ready workflows with strong

Qualifications

• PhD in Bioinformatics, Computational Biology, Genomics, Biostatistics, CS or related (or MS with substantial experience).
• Hands-on experience in developing and maintaining NGS bioinformatics pipelines.
• Proficiency in Python and/or R with reusable testable code.
• Experience with sequencing QC, alignment, variant or molecular-feature detection, and statistics.
• Understanding of experimental design, model evaluation, data quality and reproducibility.
• Linux/Unix with Git and reproducible workflows; ability to troubleshoot independently.
• Strong communication across scientific and technical teams.

Responsibilities

• Develop, optimize, and maintain end-to-end bioinformatics workflows for targeted sequencing assays.
• Process sequencing data across FASTQ, BAM/CRAM, VCF formats and intermediates.
• Develop QC metrics for sequencing performance, coverage, and sample-level performance.
• Implement methods to detect ultra-low-frequency signals in noisy data.
• Apply molecular barcodes and error-correction strategies as appropriate.
• Collaborate with assay scientists to understand sources of variation.
• Develop and evaluate statistical models to distinguish cancer signals from background.
• Assess model performance with training, tuning, and independent datasets.
• Define QC criteria, thresholds, and reproducibility requirements.
• Develop modular, version-controlled software using Python, R or similar.
• Implement reproducible workflows using Nextflow, Snakemake, or WDL; containerize and version control releases.
• Investigate pipeline failures and false positives/negatives; prepare technical verification documentation.
• Communicate findings and recommendations to diverse stakeholders.

Skills

NGS bioinformatics

Pipelines development

Python

R

Linux/Unix

Git & workflows

Statistics & study design

Troubleshooting

Education

PhD in Bioinformatics/Genomics

MS with strong experience

Tools

Python

R

Git

Unix/Linux

Nextflow/Snakemake/WDL

Job description

Yoh is seeking a Senior Bioinformatics Scientist in Sunnyvale, CA, to lead hands-on development, optimization, and validation of computational workflows for a next-generation oncology diagnostic platform. The role combines bioinformatics, NGS, statistics, and assay development within a cross-functional team.

The ideal candidate will transform sequencing data into reliable outputs, improve detection of low-frequency signals, and establish scalable, regulatory-ready workflows with strong