Senior Bioinformatics Scientist, Clinical Diagnostics

F. Hoffmann-La Roche AG; Pleasanton (CA); On-site; USD 102,000 - 168,000; Full time

Job summary

Roche is seeking a Senior Bioinformatics Scientist to support Roche Diagnostics molecular assays. You will design and maintain analytical tools for sequencing data from tumor, germline, and cfDNA samples, collaborating with bioinformaticians and wet lab scientists to optimize assay development.

The role requires strong skills in R/Python, Snakemake/Nextflow, and Linux, with a PhD or Masters in a related field and substantial industry experience in clinical diagnostics.

Qualifications

• Bachelor's degree and 7+ years of experience in bioinformatics or a related field.
• PhD in Bioinformatics, Computational Biology, Statistics, or related field with 2 years industry experience in clinical diagnostics.
• Masters in Bioinformatics, Computational Biology, Statistics, or related field with 5 years industry experience in clinical diagnostics.
• Expertise in DNA/RNA sequencing data analysis and interpretation.
• Proficiency in programming in R and/or Python, with Linux experience; C++/Java a plus.
• Strong visualization skills and ability to present complex data clearly.
• Experience building bioinformatics workflows with Snakemake or Nextflow.

Responsibilities

• Design, implement, and maintain bioinformatics tools and pipelines for clinical diagnostic assay development.
• Collaborate with biologists and wet-lab scientists to optimize high‑throughput sequencing assays.
• Troubleshoot data quality and accessibility across the diagnostic workflow for internal and external stakeholders.
• Document, train, and scale algorithms, tools, and workflows to ensure reproducibility.
• Communicate project outcomes and progress to multidisciplinary teams.

Skills

R

Python

Snakemake

Nextflow

DNA sequencing

Linux

C++

Java

Data visualization

Bioinformatics

Education

PhD in Bioinformatics or related

Masters in Bioinformatics or related

Tools

Snakemake

Nextflow

Linux

R

Python

Job description

Roche is seeking a Senior Bioinformatics Scientist to support Roche Diagnostics molecular assays. You will design and maintain analytical tools for sequencing data from tumor, germline, and cfDNA samples, collaborating with bioinformaticians and wet lab scientists to optimize assay development.

The role requires strong skills in R/Python, Snakemake/Nextflow, and Linux, with a PhD or Masters in a related field and substantial industry experience in clinical diagnostics.