Senior Bioinformatics Scientist

Roche; Pleasanton (CA); On-site; USD 102,000 - 168,000; Full time

Job summary

Roche Diagnostics seeks a Senior Bioinformatics Scientist to advance molecular assay development across NGS, Nanopore sequencing, and PCR. You will design, implement, and maintain analytical tools and workflows, collaborating with bioinformaticians, wet-lab scientists, and external customers to deliver robust diagnostics software for patient care.

You will ensure data quality, reproducibility, and scalable analyses, while contributing to cancer biology knowledge and regulatory-ready workflows in

Qualifications

• Bachelor's degree and 7+ years of experience.
• PhD with 2 years of industry experience in clinical diagnostics or related domain or Masters with 5 years of industry experience.
• Expertise in DNA/RNA sequencing data analysis and interpretation.
• Strong understanding of molecular biology and NGS laboratory processes.

Responsibilities

• Design, implement, and maintain internal algorithms and tools for clinical diagnostic assay development.
• Develop and maintain analytical tools and pipelines for processing diagnostic data from tumor, germline, and cell-free DNA samples.
• Create, implement, and streamline bioinformatics tools and workflows in partnership with wet lab scientists.
• Troubleshoot to ensure data quality, integrity, and accessibility across the diagnostic workflow.
• Advocate for best practices in documenting, training, and scaling algorithms, tools, and workflows to ensure reproducibility and scalability.
• Communicate project outcomes and team progress across various teams and organizational functions.

Skills

DNA/RNA sequencing data analysis

Bioinformatics

Programming in Python/R

Linux environment

Data visualization

Workflow management

Education

Bachelor's degree

PhD in Bioinformatics/Computational Biology/Statistics

Master's in Bioinformatics/Computational Biology/Statistics

Tools

Snakemake

Nextflow

R

Python

Job description

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

We are seeking a talented and highly motivated Senior Bioinformatics Scientist to support the development of Roche Diagnostics Molecular Assays that have a global impact on patient care. This role requires a broad understanding of assay development across diverse technologies, including NGS, Nanopore sequencing, and PCR. The successful candidate will collaborate closely with bioinformaticians, wet lab scientists, and external customers to design, implement, and maintain internal algorithms and tools for clinical diagnostic assay development.

The Opportunity

• Collaborate with multidisciplinary teams of molecular and computational biologists, as well as wet lab scientists, to design, optimize, and troubleshoot advanced high-throughput sequencing assays and workflows for clinical diagnostic applications
• Contribute bioinformatics expertise throughout the assay development lifecycle, including initial sequencing, validation, and production implementation, by developing and maintaining analytical tools and pipelines for processing diagnostic data from tumor, germline, and cell-free DNA samples
• Create, implement, and streamline bioinformatics tools and workflows in partnership with wet lab scientists to enhance assay development efficiency and data quality
• Provide hands‑on troubleshooting to ensure data quality, integrity, and accessibility across the diagnostic workflow, while addressing the needs of internal and external stakeholders through scientific and business analyses
• Advocate for best practices in documenting, training, and scaling algorithms, tools, and workflows to ensure reproducibility and scalability
• Communicate project outcomes and team progress across various teams and organizational functions to promote alignment and collaboration

Who You Are

• Required: You have a Bachelor's Degree and 7+ years of experience
• Preferred: You have a PhD in Bioinformatics, Computational Biology, Statistics, or a related field with 2 years of industry experience in clinical diagnostics or related domain or a Masters degree in Bioinformatics, Computational Biology, Statistics, or a related field with 5 years of industry experience in clinical diagnostics or a related domain
• You have expertise in DNA/RNA sequencing data analysis and interpretation
• You have a strong understanding of molecular biology principles and hands‑on familiarity with next‑generation sequencing laboratory processes

Behaviors, competencies, and qualities of the ideal applicant.

• You are proficient in programming skills in R and/or Python, with experience working in a distributed Linux environment. (Proficiency in C++ or Java is a plus)
• You are proficient in creating clear, insightful visualizations of complex biological data, with strong presentation skills
• You are skilled in writing and maintaining bioinformatics workflows using workflow management systems such as Snakemake or Nextflow
• You have a solid understanding of cancer biology and in vitro diagnostics (IVD)

Relocation benefits are not available for this posting.

The expected salary range for this position based on the primary location of California is $ 102,100 - $167 7850. Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life‑changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.