Senior Associate Scientist

Spectraforce Technologies; Cambridge (MA); On-site; USD 90,000 - 120,000; Full time

Job summary

Spectraforce Technologies in Cambridge, MA is seeking a Senior Associate Scientist to support antibody discovery projects in Biomedicine Design. This role focuses on B cell-based workflows and hybridoma screening to advance therapeutic antibody discovery campaigns.

The successful candidate will perform rodent immunization strategies, serum titer screening, flow cytometry, VH/VL cloning, and library generation while contributing to technology evaluation and collaboration with team members.

Qualifications

• Bachelor's degree in biology or related field with 2+ years laboratory experience.
• Hands-on antibody discovery experience preferred.
• Strong documentation and data organization skills.
• Effective communication of experimental results to project teams.

Responsibilities

• Provide laboratory support for antibody discovery campaigns using flow cytometry and hybridoma-based methods.
• Execute workflows for rodent immunization studies, serum titer screening, B cell sorting, and cloning.
• Maintain reagent inventories and ensure readiness for discovery activities.
• Document procedures and results in laboratory records and data systems.
• Summarize data and communicate progress to project teams.

Skills

Flow cytometry

B cell methods

Hybridoma screening

Molecular cloning

Immune library generation

Laboratory documentation

Data communication

Education

Bachelor's degree in biology/immunology/biochemistry

Tools

Flow cytometer

PCR

Cloning

Immune library generation

Hybridoma culture

Job description

Job Title: Senior Associate Scientist

Location/Site: Cambridge, MA, 02140

Duration of Assignment: 12 months

Work Schedule: Mon- Fri (100% Onsite)

Description:

Biomedicine Design's Endogenous Antibody Discovery Group is seeking a Senior Associate Scientist to support antibody discovery projects focused on B cell-based workflows. This role will contribute to therapeutic antibody discovery campaigns using rodent immunization, serum titer screening, B cell sorting by flow cytometry, immune library generation, and hybridoma-based methods. The successful candidate will execute established laboratory workflows that support immunization-based discovery, including rodent selection, immunization strategies (protein, cell-based, and genetic), serum response evaluation by ELISA, flow cytometry, VH/VL molecular cloning, immune library generation and quality control, electrofusion, and hybridoma culture and screening. The role will also contribute to the evaluation and implementation of new technologies that enhance immunization and flow cytometry-based antibody discovery workflows in collaboration with other group members.

The successful candidate should bring hands-on experience and technical capability in several of the following areas, aligned with the responsibilities of the role:

• Hands-on experience supporting antibody discovery workflows, including flow cytometry, B cell-based methods, or hybridoma-based screening.
• Working knowledge of molecular biology techniques such as PCR, cloning, and immune library generation or related sample preparation workflows.
• Experience with laboratory documentation, data organization, and communicating experimental results clearly to project teams.
• Strong laboratory organization skills, including reagent handling, inventory support, and maintaining materials needed for experimental workflows.

Responsibilities:

• Provide laboratory support for therapeutic antibody discovery campaigns using flow cytometry, immune library generation, and hybridoma-based methods.
• Execute established workflows to support rodent immunization studies, serum titer screening, B cell sorting, molecular cloning, and related sample processing activities.
• Maintain reagent inventories, prepare laboratory materials, and ensure operational readiness for discovery activities.
• Document experimental procedures, results, and observations accurately in laboratory records and internal data systems.
• Summarize data and communicate key findings, experimental progress, and campaign outcomes to project teams.

Nice-to-have skills:

• Experience with flow cytometry-based analysis or cell sorting.
• Experience with laboratory automation or high-throughput workflows.
• Experience working with rodents, particularly mice, in a research setting.
• Experience working with hybridoma generation, culture, or screening workflows.

Qualifications:

• Bachelor's degree in biology, immunology, molecular biology, biochemistry, or a related scientific discipline, with at least 2 years of full-time laboratory experience in an academic or industry setting.