Senior Asset Reliability & Maintenance Manager

AstraZeneca GmbH; Los Angeles (CA); On-site; USD 119,000 - 178,000; Full time

Benefits offered by this job

Incentives

Equity‑based awards

Retirement program

Paid time off

Health, dental, and vision coverage

Job summary

AstraZeneca GmbH seeks a senior maintenance leader to mature the site RAM framework, planning, scheduling, and MRO storeroom management for cell therapy manufacturing and related facilities. You will drive data-driven maintenance strategies and ensure uninterrupted operations in a highly regulated biopharma setting.

Collaborating with Manufacturing, Engineering, Quality, Validation, Supply Chain, Warehouse, Automation, and EHS, you will optimize maintenance practices, manage budgets, and mentor

Qualifications

• 7+ years of experience in maintenance, reliability, facilities, or engineering in a regulated manufacturing environment.
• 3+ years of leadership experience managing maintenance teams, planners, supervisors, or technical support personnel.
• Experience in biopharmaceutical, medical device, cell therapy, gene therapy, aseptic manufacturing, or another highly regulated industry.
• Demonstrated experience developing or improving maintenance planning and scheduling processes.
• Demonstrated experience managing or optimizing an MRO storeroom and spare parts strategy.
• Experience using CMMS/EAM systems such as SAP PM, Maximo, or similar platforms.

Responsibilities

• Lead the site maintenance function supporting cell therapy manufacturing, laboratories, critical utilities, and facility systems.
• Develop and implement a structured maintenance planning and scheduling process, including work identification, prioritization, backlog management, weekly scheduling, and schedule compliance review.
• Establish and sustain effective CMMS-based work management processes for preventive, predictive, corrective, and emergency maintenance.
• Improve RAM performance by analyzing equipment history, downtime trends, failure modes, and maintenance efficiency, then translating findings into practical reliability improvements.
• Optimize preventive and predictive maintenance strategies to improve uptime, reduce recurring failures, and increase planned work execution.
• Lead MRO storeroom improvement efforts, including spare parts governance, critical spares identification, inventory accuracy, min/max optimization, and service level improvement.
• Define and oversee maintenance KPIs such as PM completion, schedule compliance, planned versus unplanned work, backlog age, MTBF, MTTR, equipment uptime, and storeroom performance.
• Partner with cross-functional teams to investigate equipment issues, support root cause analysis, and implement corrective and preventive actions.
• Ensure compliance with GMP/GxP requirements, site procedures, documentation standards, change control, deviation management, and audit readiness expectations.
• Handle maintenance resources, including internal team members, contractors, and service providers, to deliver safe and efficient maintenance execution.
• Support shutdown and maintenance window planning to increase work quality and minimize operational disruption.
• Manage budgets and costs associated with maintenance labor, contractors, and spare parts inventory while maintaining compliance and reliability standards.
• Mentor and develop the maintenance team through clear expectations, training, performance management, and standard work practices.

Skills

Leadership

CMMS/EAM

Maintenance Planning

Reliability Metrics

Cross-functional Collaboration

GxP Compliance

Education

Bachelor’s degree in Engineering or related field

Tools

SAP PM

Maximo

Job description

AstraZeneca GmbH seeks a senior maintenance leader to mature the site RAM framework, planning, scheduling, and MRO storeroom management for cell therapy manufacturing and related facilities. You will drive data-driven maintenance strategies and ensure uninterrupted operations in a highly regulated biopharma setting.

Collaborating with Manufacturing, Engineering, Quality, Validation, Supply Chain, Warehouse, Automation, and EHS, you will optimize maintenance practices, manage budgets, and mentor