Senior Analytical Scientist – Peptide Discovery

Pro Staff; Menlo Park (CA); On-site; USD 85,000 - 100,000; Full time

Benefits offered by this job

Medical, dental, vision

401(k) Retirement Savings Plan

Employee Assistance Program (EAP)

Commuter/Parking Accounts

Health Savings Account (HSA)

AD&D Insurance

Job summary

Staffmark is seeking a Senior Analytical Scientist for a consulting opportunity in Menlo Park, CA. The role focuses on advanced peptide discovery with nanoLC-MS/MS using Thermo Orbitrap instrumentation, including method development and data interpretation.

The candidate will perform high-sensitivity analyses, optimize acquisition parameters, and support peptide hit identification while maintaining instrument performance and documentation.

Qualifications

• MS or PhD in Analytical Chemistry, Biochemistry, Mass Spectrometry, or related field.
• 3+ years of hands-on nano-flow LC-MS/MS experience on Thermo instrumentation.
• Experience operating Thermo Orbitrap instruments and Xcalibur software.
• Strong knowledge of peptide MS/MS fragmentation and database-based sequence identification.
• Experience developing and optimizing nanoLC-MS workflows.

Responsibilities

• Perform high-sensitivity nano-flow LC-MS/MS analysis of peptide samples.
• Develop and optimize nanoLC-MS/MS methods and MS/MS acquisition parameters.
• Configure and operate Thermo Orbitrap XL and Thermo Dionex UltiMate 3000 NanoLC system.
• Analyze and interpret LC-MS/MS data for peptide sequence identification.
• Perform instrument maintenance, calibration, troubleshooting, and performance optimization.
• Resolve nanoLC system issues involving flow paths, columns, emitters, and electrospray stability.
• Document analytical methods, results, and recommendations.
• Collaborate with scientific teams to support peptide hit identification.

Skills

NanoLC-MS/MS

Mass spectrometry

Method development

Data analysis

Education

MS or PhD in Analytical Chemistry, Biochemistry, Mass Spectrometry, or related field

Tools

Thermo Orbitrap mass spectrometers

Xcalibur software

Thermo Orbitrap XL

Thermo Dionex UltiMate 3000 NanoLC

Job description

Staffmark is seeking a Senior Analytical Scientist for a consulting opportunity in Menlo Park, CA. The role focuses on advanced peptide discovery with nanoLC-MS/MS using Thermo Orbitrap instrumentation, including method development and data interpretation.

The candidate will perform high-sensitivity analyses, optimize acquisition parameters, and support peptide hit identification while maintaining instrument performance and documentation.