Senior ADC Analytics Scientist – Mass Spec & Developability

Gilead Sciences Inc.; Foster City (CA); On-site; USD 169,000 - 219,000; Full time

Job summary

Gilead Sciences Inc. in Foster City, CA, seeks a Senior Scientist, Protein Therapeutics, to strengthen ADC analytics, applying mass spectrometry and developability assessment to inform program decisions.

You will design analytical experiments for antibody-drug conjugates, optimize methods (LC-MS, peptide mapping, chromatography), evaluate DAR and payload stability, and mentor junior scientists in a collaborative, scientifically rigorous team.

Qualifications

• Bachelor's Degree and 8 Years' Experience
• Master's Degree and 6 Years' Experience
• PhD and 2 Years' Experience
• Industry experience supporting ADC discovery or development programs.
• Deep expertise in protein and ADC analytical characterization, including native and denaturing LC-MS, peptide mapping, HIC, SEC, RP, IEX, CE-SDS, and cIEF.
• Experience with multidimensional chromatography (2D-LC) for biologics/ADCs, including HIC-RP-MS, SEC-RP-MS, IEX-RP-MS.
• Knowledge of ADC pharmacokinetics, metabolism, and bioanalytical considerations.
• Excellent critical thinking, experimental design, troubleshooting, and problem-solving skills.
• Strong written and verbal communication skills.

Responsibilities

• Independently design and execute analytical characterization experiments for antibody-drug conjugates (ADCs) to support discovery and candidate selection.
• Develop, optimize, and troubleshoot advanced analytical methods, including high-resolution LC-MS (intact and subunit mass analysis), peptide mapping, multidimensional chromatography, and plate-based workflows to improve analytical robustness and throughput.
• Evaluate key ADC attributes, including DAR, aggregation, fragmentation, hydrophobicity, charge heterogeneity, and linker-payload stability, and integrate data to identify risks and support progression decisions.
• Apply scientific judgment to resolve complex analytical challenges and independently select approaches for novel assignments.
• Evaluate, implement, and advance emerging analytical technologies and workflows to expand ADC characterization capabilities and improve efficiency.
• Promote ADC characterization best practices, ensuring high-quality experimental design, data integrity, and documentation in ELN and data management systems.
• Present scientific findings, conclusions, and recommendations to cross-functional teams.
• Contribute to scientific publications, patents, technical reports, and external scientific engagement where appropriate.
• Mentor junior scientists and foster a collaborative, innovative, and scientifically rigorous team environment.

Skills

Mass spectrometry

Protein analytics

Developability assessment

ADC characterization

Analytical chemistry

Education

PhD in analytical chemistry

Master's degree in analytical chemistry

Bachelor's degree in chemistry

Tools

LC-MS

2D-LC

HIC

SEC

RP-HPLC

IEX

CE-SDS

cIEF

Job description

Gilead Sciences Inc. in Foster City, CA, seeks a Senior Scientist, Protein Therapeutics, to strengthen ADC analytics, applying mass spectrometry and developability assessment to inform program decisions.

You will design analytical experiments for antibody-drug conjugates, optimize methods (LC-MS, peptide mapping, chromatography), evaluate DAR and payload stability, and mentor junior scientists in a collaborative, scientifically rigorous team.