Scientist, Upstream Process Development

Scorpion Therapeutics; Spring House (PA); On-site; USD 90,000 - 150,000; Full time

Job summary

Scorpion Therapeutics in Spring House, PA is seeking an Upstream Process Development Scientist to scale cell culture processes for in vivo biologics and gene therapies. You will design and execute development studies across shake flasks, bioreactors, and high-throughput platforms, and optimize fed-batch and perfusion strategies.

The role requires hands-on bioreactor operation, proficiency with Ambr 250 systems, and strong data analytics using JMP, MiniTab or Python to drive process understanding

Qualifications

• BS/MS in Chemical/Biochemical Engineering, Biological Sciences, or related field.
• 2–4+ years’ experience in mammalian cell culture process development.
• Hands-on bioreactor operation and scale-up experience.

Responsibilities

• Design and execute development studies using shake flasks, bioreactors, and high-throughput systems.
• Optimize fed-batch and perfusion processes for mammalian cells.
• Utilize Ambr 250 bioreactors in development work.
• Apply statistical design and data analytics to enable process understanding.
• Support evaluation of novel technology and cross-functional collaboration.
• Author technical and regulatory documentation.

Skills

Bioreactor ops

Cell culture

Data analysis

Python

Ambr 250

Education

BS/MS in relevant field

Tools

JMP

MiniTab

Job description

Role

Upstream Process Development Scientist supporting scalable cell culture processes for in vivo biologics and gene therapies.

Responsibilities

• design and execute development studies using shake flasks, bioreactors, and high-throughput systems
• optimize fed-batch and perfusion processes
• utilize Ambr 250 bioreactors
• apply statistical design and data analytics
• support novel technology evaluation
• collaborate with cross-functional teams
• author technical and regulatory documentation.

Requirements

• BS/MS in Chemical/Biochemical Engineering, Biological Sciences, or related
• 2-4+ years’ experience in mammalian cell culture process development
• hands‑on bioreactor operation, media optimization, and process scale‑up experience
• proficiency with Ambr 250 systems, data analysis tools (JMP, MiniTab, Python).

HighValue:

biologics, gene therapy, RNA therapeutics, viral vectors; process development from early to clinical stages; use of digital bioprocessing tools, Process Analytical Technology, and scale‑down modeling; cross‑functional collaboration; location in Spring House, PA with potential for cross-team interaction.