Associate Scientist, Upstream Process Development

Bayside Solutions; California (MO); On-site; USD 75,768 - 89,544; Full time

Job summary

A biotechnology firm is seeking an Associate Scientist for their Bioprocess Development team. The candidate will prepare, execute, and document upstream process runs to support the large molecule pipeline. This role requires a BA/BS or MS in a scientific discipline with at least 2 years of experience in mammalian cell culture and direct experience with benchtop bioreactors. Excellent attention to detail and the ability to manage multiple experiments are essential. Competitive pay rate between $55 and $65 per hour is offered.

Qualifications

• 2+ years of mammalian cell culture experience in the biotech/biopharma industry.
• Direct experience operating benchtop bioreactors.
• Good understanding of CHO cell culture fundamentals and feeding strategies.

Responsibilities

• Execute lab-scale fed-batch bioreactor experiments to support process development.
• Maintain and troubleshoot key laboratory equipment.
• Document all experiments in an electronic lab notebook.

Skills

Upstream process development

Bioprocess development

Mammalian cell culture

CHO cell culture

Fed-batch bioreactor operations

Bioreactor performance troubleshooting

Attention to detail

Education

BA/BS or MS degree in a related scientific discipline

Tools

AMBR250 bioreactor systems

Vi-CELL

Nova Flex2

Octet

Job description

Associate Scientist, Upstream Process Development

W2 Contract

Pay Rate: $55 - $65 per hour

Job Summary:

We are seeking to hire an Associate Scientist to join our Bioprocess Development team. The successful candidate will be responsible for preparing, executing, and documenting upstream process runs to support our large molecule pipeline.

Duties and Responsibilities:

• Execute lab-scale fed-batch bioreactor experiments (e.g., AMBR250, benchtop STRs) to support process development, optimization, characterization, and material generation.
• Operate, maintain, and troubleshoot key laboratory equipment such as Vi-CELL, Nova Flex2, Octet, AMBR250, and bench-scale bioreactors.
• Identify, communicate, and resolve bioreactor performance issues (e.g., pH, DO, feeding, sensor drift, contamination risks).
• Summarize key experimental data and document all experiments in an electronic lab notebook in a timely and compliant manner.
• Adhere to established protocols, maintain strong sterile technique, and ensure experimental reproducibility.

Requirements and Qualifications:

• BA/BS or MS degree in biology, biochemistry, chemical engineering, or related scientific discipline with 2+ years of mammalian cell culture experience in the biotech/biopharma industry
• Direct experience operating benchtop bioreactors (e.g., AMBR250 or similar systems).
• Good understanding of CHO cell culture fundamentals, feeding strategies, and basic metabolic principles (e.g., lactate, ammonia, osmolality control).
• Demonstrated ability to work independently and manage multiple experiments simultaneously.
• Excellent attention to detail and documentation discipline.

Desired Skills and Experience

• Upstream process development
• Bioprocess development
• Mammalian cell culture
• CHO cell culture
• Fed-batch bioreactor operations
• AMBR250 bioreactor systems
• Bench-top stirred tank bioreactors (STRs)
• Bioreactor process optimization
• Bioreactor process characterization
• Bioprocess scale-down models
• Cell culture feeding strategies
• Bioreactor performance troubleshooting
• pH and dissolved oxygen (DO) control
• Metabolic analysis (lactate, ammonia, osmolality)
• Sterile technique and aseptic processing
• Laboratory instrumentation operation (Vi-CELL, Nova Flex2, Octet)
• Process development experimentation
• Experimental design and execution
• Electronic lab notebook (ELN) documentation
• Data analysis and experimental data summarization
• Process reproducibility and protocol adherence
• Biopharmaceutical process development
• Large molecule biologics development
• Laboratory equipment maintenance and troubleshooting
• Independent experiment management
• Multi-experiment project coordination
• Scientific documentation and compliance
• Attention to detail in laboratory research

Bayside Solutions, Inc. is not able to sponsor any candidates at this time. Additionally, candidates for this position must qualify as a W2 candidate.