Scientist/Sr. Scientist - Mass Spectrometry

Prellis Biologics; Berkeley (CA); On-site; USD 110,000 - 144,000; Full time

Job summary

A leading company in biotechnology is seeking a Scientist or Senior Scientist to join their Protein Sciences team. The ideal candidate will have expertise in mass spectrometry and protein biochemistry, contributing to drug discovery through analytical workflows. Responsibilities include managing purification processes and collaborating across teams to support research initiatives. This role offers competitive pay and the opportunity to work on innovative projects.

Benefits

Medical insurance

Vision insurance

401(k)

Qualifications

• 10+ years experience with BS, 8+ with MS, or 2+ with PhD.
• Demonstrated expertise in mass spectrometry for protein characterization.
• Hands-on experience with AKTA purification systems.

Responsibilities

• Design and execute workflows to characterize proteins and peptides.
• Independently manage high-throughput IgG purification workflows.
• Collaborate across teams to deliver high-quality analytical support.

Skills

mass spectrometry

protein biochemistry

IgG purification

protein chromatography

peptide/protein conjugation

Education

BS/MS/PhD in Chemistry

Tools

AKTA purification systems

LC-MS/MS

LC-QTOF/MS

Job description

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This range is provided by Prellis Biologics. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$110,000.00/yr - $144,000.00/yr

Prellis Biologics uses proprietary technology to 3D print lymph node organoids, enabling the generation of in vitro antibody libraries and human lymph node cocultures for producing antigen-specific B-cells. We are seeking a Scientist or Senior Scientist to join our Protein Sciences team with deep expertise in mass spectrometry and protein biochemistry. This role reports to the Scientific Director of Platforms and will be responsible for developing and implementing analytical and preparative workflows across our discovery pipeline.

The ideal candidate will have strong mass spectrometry skills, plus hands-on experience with high-throughput IgG purification, AKTA-based protein chromatography, and peptide/protein chemical conjugation. You’ll work cross-functionally to support early drug discovery and contribute broadly to multiple platforms.

Key Responsibilities

• Design and execute LC-MS/MS and LC-QTOF/MS workflows to characterize proteins, peptides, drug substances, and intermediates.
• Perform intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping).
• Independently manage high-throughput IgG purification workflows, including optimization for yield and throughput.
• Operate and maintain AKTA FPLC systems for antibody/protein purification and method development.
• Develop and perform protein and peptide conjugation protocols, including linker chemistry and small-molecule attachments (e.g., for ADCs).
• Troubleshoot MS and purification assays, analyze complex datasets, and document results with scientific rigor.
• Interact with external vendors for service and maintenance of mass spectrometry and chromatography instrumentation.
• Collaborate across Discovery, Screening, and Functional Biology teams to deliver high-quality analytical support.
• Maintain a high degree of autonomy in lab operations, problem solving, and data interpretation.
• Communicate findings effectively in team meetings, technical reports, and cross-functional updates.

Qualifications

• BS/MS/PhD in Chemistry, Biochemistry, or related discipline with:
• 10+ (BS), 8+ (MS), or 2+ (PhD) years of relevant industry experience.
• Demonstrated expertise in mass spectrometry for protein and peptide characterization.
• Hands-on experience with AKTA purification systems and column chromatography techniques.
• Strong working knowledge of IgG purification, especially in high-throughput screening contexts.
• Experience with protein/peptide conjugation chemistry for bioconjugates, linkers, or drug attachments.
• Deep understanding of analytical method development and biophysical characterization.
• Familiarity with peptide synthesis or downstream functional assay support is a plus.
• Ability to thrive in a fast-paced, collaborative environment and adapt across workflows.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research and Science

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Inferred from the description for this job

Medical insurance

Vision insurance

401(k)

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