Scientist/ Research Associate – AI Protein Design

SystImmune Inc.; Redmond (WA); On-site; USD 80,000 - 180,000; Full time

Job summary

An innovative bio-pharmaceutical company seeks a Protein Design Scientist to enhance its Computational Protein Design pipeline. This role involves utilizing data-driven methods to design novel peptides and proteins, focusing on multi-specific biological programs. The ideal candidate will have a PhD and extensive experience in computational methods and macromolecular modeling software. Join a dynamic team dedicated to advancing cancer treatments through cutting-edge science and collaboration. This is an exciting opportunity to contribute to groundbreaking therapies in a rapidly evolving field.

Qualifications

• 8+ years of experience in protein binding or therapeutic antibody generation.
• Experience with macromolecular modeling software is essential.

Responsibilities

• Execute computational design for predicting peptide properties.
• Collaborate with teams to drive protein discovery and development.

Skills

Computational Protein Design

Structural Modeling

Data-Driven Approaches

Peptide Design

Protein Optimization

Education

PhD in Bioengineering or related field

Tools

AlphaFold

RoseTTAFold

RFdiffusion

ProteinMPNN

Gromacs

MOE

Schrödinger

Job description

SystImmune Inc. is a clinical-stage bio-pharmaceutical company dedicated to developing innovative treatments for cancer through breakthrough-therapeutic multi-specific antibodies and antibody-drug conjugates (ADCs). With eight assets in ongoing clinical trials and a robust preclinical pipeline, we are seeking a talented Protein Design Scientist or Senior Scientist to join our AI drug design group.

Job Summary:

We are looking for a creative and motivated individual to execute and improve our Computational Protein Design pipeline using data-driven approaches to augment our first-in-class multi-specific biological programs. The ideal candidate will have experience applying computational methods to design novel peptides and proteins, with expertise in structural modeling, prediction, and optimization.

Essential Duties and Responsibilities:

• Execute a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody-based elements via data-driven approach.
• Drive assay validation, tech transfer, and development initiatives to maintain industry standards; contribute within the computational protein design group to operate yeast display-based protein discovery platforms.
• Design new macromolecular therapeutics using structural and sequence analysis, and employ these in silico predictions to iteratively guide the lead development process.
• Analyze, interpret, document, and present data to the scientific and leadership team.
• Collaborate with our Antibody Discovery, Protein Engineering, and Immuno-oncology teams to contribute to the company's vision.

Qualifications:

• PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field.
• 8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies required.
• Experience with relevant macromolecular modeling software (e.g., AlphaFold, RoseTTAFold, RFdiffusion, ProteinMPNN, Gromacs, MOE, Schrödinger).
• Expertise in screening and ranking of antibodies (ELISA, multi-parametric flow cytometry, BLI/OCTET).
• Proven contribution to therapeutic antibody development and selection is desirable; design and validation of novel biologically relevant antibodies are highly desirable.

Compensation and Benefits:

The hiring pay range for this position is $80,000 - $180,000 per year based on skills, education, and experience relevant to the role.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.