Scientist, Process Analytics - Synthetic Molecules

Takeda; Cambridge (MA); Presencial; USD 116 000 - 182 000; Tempo integral

Resumo da oferta

Takeda is seeking a Scientist, Process Analytics in Cambridge, MA to drive analytical method development for process chemistry and enable scale-up and tech transfer. The role leads analytical experiments and data interpretation to improve drug substance processes.

You will collaborate across chemistry, analytical development, and engineering while advancing PAT/HTE initiatives and delivering innovative analytics solutions in a dynamic team environment.

Qualificações

• Bachelor’s degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science and 5+ years relevant industry experience
• Master’s degree in chemistry, biology, pharmacy, engineering, or related pharmaceutical science; 3+ years relevant industry experience
• PhD in chemistry, biology, pharmacy, engineering, or related pharmaceutical science; 0+ years relevant industry experience
• Working knowledge of modern analyses for small molecule pharmaceuticals, particularly HPLC, GC, LC-MS, and associated analytical software and data processing platforms, such as Empower / Openlab
• Good understanding of synthetic organic chemistry
• Analytical and Problem-Solving Skills - Able to troubleshoot critical issues or problems and determine causes and workable solutions.
• Teamwork – Ability to work well in highly cross functional team environment and across global line functions
• Communication Skills -Able to express oneself clearly and concisely within team; documents issues and/or concerns concisely with colleagues; adjusts communication style as appropriate for the audience; timely and effectively communicates issues to supervisor; technical writing skills to support authorship of internal technical documents.
• Organization – Exercises time management and prioritization skills and can successfully manage multiple tasks simultaneously.
• Knowledge Sharing: Ability to capture organizational knowledge; improve solutions, processes, and deliverables through information; improve information capital by contributing experience, theories, deliverables, and models for others to use.
• Resource Management -Ability to manage one’s time within individual, departmental, and corporate goals, and timelines; management of internal and external resources (vendors).
• External Involvement – Demonstrated involvement in professional community evidenced by presentation of scientific posters or lectures at professional conferences or events.
• Able to interpret results of complex experiments and integrate data produced by other disciplines.
• Able to work in lab setting.
• Proficiency with utilizing typical literature searching techniques to solve technical problems.
• May require 5-10% travel.

Responsabilidades

• Design and execute drug substance process development analytical activities including phase-appropriate method development, preliminary isolation/identification of process impurities, understanding reaction kinetics/mechanism, and data management.
• Collaborate with drug substance process chemistry, analytical development and engineering to design and execute experiments for process optimization, scale-up, and technology transfer activities.
• Execution of analytical testing’s for small molecule pharmaceuticals, such as HPLC, LC-MS, GC, KF, NMR, and solid state characterizations (XRPD, DSC, TGA, DVS) when needed
• Identify critical in-process-control issues and develop appropriate IPC methods
• Provide analytical support and expertise to troubleshoot process-related issues and implement corrective actions.
• Method development support for innovation and technology team, including support for Process Analytical Technology (PAT) and High throughput experimentation (HTE) teams.
• Analyze and interpret analytical data to assess process performance, identify trends, and make data-driven decisions to improve process efficiency and product quality.
• Stay updated on emerging trends and advancements in analytical chemistry, and process optimization methodologies. Identify opportunities for continuous improvement in analytical techniques, processes, and systems.
• Technology advancement: work cross-functionally to ensure continued innovation for the PA team and SMPD.
• Platform consolidation of analytical data so that chemists and engineers can easily access data, accelerate processing time, and integrate results.
• Contribute to complex/multiple projects or functional areas through leading or influencing others.
• Influence and support initiatives related to driving scientific and technical improvement within function and potentially cross-functionally.
• Ensure a productive and development-rich environment.
• Define more complex/novel approaches and methodologies to solving complex technical challenges.
• Identify vendors and build relationships to gain access to technologies as needed to deliver pipeline goals.
• Understand project timelines and deliverables and plan/coordinate project work accordingly with departmental, functional, and external stakeholders.
• Provide technical leadership to project teams within area of expertise.
• Contribute significantly and independently to project work which may include multiple projects within functional area.
• Review, interpreting and communicating data cross-functionally within CMC (Chemistry, Manufacturing & Controls) and project teams.
• Plan and implement resolutions to technical problems/issues.
• Independently design and execute experiments, and reports results.
• Responsible for integrating scientific/technical efforts around cross-functional issues.

Conhecimentos

Analytical skills

Collaboration

Communication skills

Organization

Problem-solving

Literature search

Formação académica

Bachelor’s degree in chemistry/biology/engineering

Master’s degree in chemistry/biology/engineering

PhD in chemistry/biology/engineering

Ferramentas

Empower/Openlab

HPLC/GC/LC‑MS

Descrição da oferta de emprego

Takeda is seeking a Scientist, Process Analytics in Cambridge, MA to drive analytical method development for process chemistry and enable scale-up and tech transfer. The role leads analytical experiments and data interpretation to improve drug substance processes.

You will collaborate across chemistry, analytical development, and engineering while advancing PAT/HTE initiatives and delivering innovative analytics solutions in a dynamic team environment.