Principal Scientist I (I/O - In Vitro/Ex Vivo)

ModeX Therapeutics, Inc.; Weston (MA); On-site; USD 180,000 - 197,000; Full time

Job summary

ModeX Therapeutics is seeking a Senior Scientist with deep hands-on Immuno-oncology/Immunology expertise to advance novel biologic therapies. You will design, execute, and interpret cell-based studies using primary immune cells, characterize mechanisms of action, and address key biological questions at the bench.

You'll independently develop and optimize in vitro/ex vivo assays, apply multicolor flow cytometry, and analyze data across projects while mentoring junior team members in a fast-paced

Qualifications

• PhD in Immunology, Cancer Biology, or related field with 12+ years research, incl. 4+ years in biotech R&D.
• Proven experience in discovery/preclinical biologics, immunology/immuno-oncology preferred.
• Independent scientist with strategy development and data-driven recommendations.
• Strong hands-on Immunotherapy/Immunology expertise and ability to apply new assays.
• Experience designing/ executing functional assays with primary immune cells and multi-parameter flow cytometry.
• Extensive flow cytometry panel design, data analysis; spectral flow desirable.
• Proven ability to work independently, prioritize, and drive projects forward.
• Excellent written/oral communication; collaborate across teams.
• Mentorship ability for junior team members.

Responsibilities

• Develop biologic drugs for Immunotherapy from concept to candidate advancement.
• Design, execute, analyze, and interpret in vitro/ex vivo studies to characterize drug candidates and their mechanisms of action.
• Develop, optimize and troubleshoot complex immune cell-based assays using primary immune cells, tumor cell lines, reporter systems, and co-culture models.
• Provide subject matter expertise in multicolor flow cytometry, panel design and optimization, data analysis, and troubleshooting.
• Critically analyze and integrate experimental data across studies, identify gaps, and provide independent data-driven recommendations.
• Take ownership of assigned research areas or project workstreams, driving studies to completion with independence.
• Maintain awareness of literature and tech developments to inform strategies.
• Collaborate cross-functionally with discovery, translational and project teams for data-driven decisions.
• Contribute to scientific reports and presentations, communicating findings to teams.
• Maintain accurate documentation and ensure compliance with lab standards.

Skills

Immunology

Flow cytometry

Cell-based assays

Data analysis

Project leadership

Education

PhD in Immunology

Tools

Spectral flow cytometry

ELISA

Luminex

MSD

Job description

#762

WESTON, Massachusetts, United States

Position Type

Full-time (30+ Hours)

Work Schedule

Monday-Friday 8:30am-5:00pm

Job Description

ModeX Therapeutics is seeking a highly skilled and motivated Senior Scientist with strong hands-on experience in Immuno-oncology/Immunology to support the development and progression of novel immune therapies . The successful candidate will design, execute, and interpret cell-based studies using primary immune cells and relevant assay systems to evaluate biologic drug candidates, characterize their mechanism of action, and address biological questions . This is an exciting opportunity for a collaborative scientist who enjoys working at the bench, brings strong biological insight, and wants to contribute to the development of next-generation therapeutics in a fast-paced, rapidly growing biotech company with a bold vision.

Key Responsibilities:

• Play a key role in the development of new biologic drugs for Immunotherapy and Immunology; contributing from early concept generation through candidate advancement
• Independently design, execute, analyze, and interpret in vitro/ex vivo studies to characterize drug candidates and their mechanisms of action
• Develop, optimize and troubleshoot complex immune cell-based functional assays using primary immune cells (human and mouse), tumor cell lines, reporter systems, and co-culture models
• Provide subject matter expertise in multicolor flow cytometry, including panel design and optimization, data analysis, and troubleshooting
• Critically analyze and integrate experimental data across studies, identify key scientific gaps, draw clear conclusions, and provide independent data-driven recommendations for program direction and next steps
• Take ownership of assigned research areas or project workstreams, establishing experimental priorities and driving studies to completion with a high degree of scientific independence
• Maintain awareness of relevant scientific literature, emerging technologies, competitive programs, and industry developments, and apply these insights to therapeutic and experimental strategy
• Collaborate cross-functionally with discovery, translational and project teams to ensure data-driven decision-making and timely progression of programs.
• Contribute to scientific reports, presentations, and project updates, and effectively communicate findings to cross-functional teams
• Maintain accurate documentation of experimental activities and ensure compliance with applicable laboratory standards and data integrity practices.

Qualifications:

• D. in Immunology, Cancer Biology, Cell biology, Immuno-oncology, or a related scientific field, with 12+ years of relevant research experience, including at least 4+ years in a biotech or pharmaceutical R&D environment
• Demonstrated experience in the discovery and/or preclinical development of biologic therapeutics, preferably in immunology or immuno-oncology
• Strong track record of functioning as an independent scientist, including developing experimental strategies, designing complex studies, troubleshooting technical challenges, interpreting multidisciplinary datasets, and recommending next steps
• Strong, hands-on expertise in Immunotherapy and Immunology, with the ability to independently evaluate and apply new concepts and immunoassays
• Demonstrated experience designing, executing, and interpreting functional assays using primary immune cells, including multi-parameter flow cytometry, cytokine profiling (ELISA, MSD, Luminex, or equivalent), immune activation, proliferation, and cytotoxicity assays.
• Extensive hands-on experience with flow cytometry panel design, optimization, and data analysis; spectral flow cytometry experience is desirable
• Proven ability to work independently, prioritize effectively, and drive projects forward in a fast-paced biotech environment
• Excellent written and oral communication skills, including the ability to present complex data clearly to scientific and cross-functional audiences
• Strong troubleshooting, organization, data analysis, and problem-solving skills
• Highly collaborative mindset with the ability to contribute ideas, work across teams, and mentor junior team members as needed

ModeX Therapeutics is an Equal Opportunity Employer

Pay Range

The estimated pay range for this job. Disclosing pay information promotes competitive and equitable pay.
The actual pay rate will depend on the person's qualifications and experience. $180,000.00 - $197,000.00 / year

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