Scientist II - LNP Formulation

The Fountain Group; San Diego (CA); On-site; USD 110,000 - 140,000; Full time

Job summary

The Fountain Group is seeking a LNP Formulation Scientist for a San Diego, CA position. You will formulate and optimize LNPs encapsulating nucleic acids and execute DoE screening to optimize compositions and processing parameters.

You will characterize LNPs using DLS, zeta potential, Ribogreen, analyze data, maintain records, support scale-up and stability studies, and collaborate with cross-functional teams to meet formulation requests.

Qualifications

• Bachelor's or Master's with biopharma industry experience; 5+ years or 2+ years with master's.
• 2+ years hands-on LNP formulation experience with nucleic acid encapsulation.
• Experience with LNP characterization: DLS, zeta potential, Ribogreen assays.
• Strong Excel skills and high data integrity in documentation.

Responsibilities

• Formulate and optimize LNPs encapsulating nucleic acids.
• Execute DoE screening campaigns to evaluate LNP compositions and processing parameters.
• Characterize LNPs and interpret and present experimental results.
• Support early-stage formulation development, cryoprotection, scale-up, and stability studies.
• Maintain detailed lab records and support routine lab operations, including inventory and buffer prep.
• Collaborate with cross-functional teams to fulfill formulation requests.

Skills

LNP formulation

DoE screening

Nucleic acid encapsulation

DLS

Zeta potential

Ribogreen assays

Excel

Data analysis

Documentation

Communication skills

Education

Bachelor's degree in Chemistry/Biochemistry/Chemical Engineering

Master's degree in related field

Tools

JMP

GraphPad Prism

Job description

The Fountain Group is currently seeking a LNP Formulation Scientist for a prominent client of ours. This position is located in San Diego, CA. Details for the position are as follows:

Job Description:

• Formulate and optimize LNPs encapsulating nucleic acids, including mRNA, siRNA, or DNA.

• Execute Design of Experiments (DoE) screening campaigns to evaluate LNP compositions and processing parameters.

• Characterize LNPs and analyze, interpret, and present experimental results.

• Support early-stage formulation development, cryoprotection, scale-up, and stability studies as needed.

• Maintain detailed laboratory records and support routine lab operations, including inventory, ordering supplies, buffer preparation, and autoclaving.

• Collaborate with cross-functional teams to fulfill formulation requests.

Qualifications:

• Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related field with 5+ years of biopharma industry experience, or a Master's degree with 2+ years of industry experience.

• 2+ years of hands-on LNP formulation experience, including nucleic acid encapsulation.

• Experience with LNP characterization techniques, including:

  • Dynamic Light Scattering (DLS)

  • Zeta potential

  • Ribogreen assays

• High proficiency in Microsoft Excel.

• Strong data analysis, documentation, organizational, and communication skills.
• Demonstrated attention to detail and ability to generate reproducible experimental data.

Preferred Qualifications

• Experience preparing targeted LNPs, including mAb-, Fab-, scFv-, or VHH-coated LNPs.

• Experience with immune cell delivery.

• Familiarity with statistical and data analysis software such as JMP or GraphPad Prism.

• Experience with DoE-based formulation screening.

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