Scientist II – LNP Formulation

Pharmaceutical Company; San Diego (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

Pharmaceutical Company in San Diego seeks a Scientist II to lead hands-on lipid nanoparticle (LNP) formulation for nucleic acid delivery, including mRNA, siRNA, or DNA. The role emphasizes practical formulation work and data-driven optimization onsite.

You will operate LNP equipment (T-mixer, NanoAssemblr) and collaborate with project teams to advance formulation development, analyze results, and ensure safety and quality practices in the lab.

Qualifications

• Hands-on LNP formulation experience in biopharmaceuticals.
• Experience encapsulating nucleic acids (mRNA, siRNA, or DNA).
• Experience supporting formulation development or process optimization.
• Ability to work on-site.

Responsibilities

• Perform hands-on lipid nanoparticle formulation for nucleic acid delivery applications.
• Encapsulate nucleic acids into LNPs.
• Support formulation development, process optimization, and experimental troubleshooting.
• Operate LNP formulation equipment (T-mixer and NanoAssemblr).
• Perform LNP characterization and analyze experimental results.
• Document experiments, interpret data, and communicate findings to project teams.
• Follow laboratory procedures and applicable safety and quality practices.

Skills

LNP formulation experience

Nucleic acid encapsulation

Formulation development support

On-site work capability

Education

Bachelor's degree in a relevant science

Master's degree preferred

PhD candidates with LNP experience considered

Tools

T-mixer

NanoAssemblr systems

Job description

We are seeking a Scientist II with hands-on experience in lipid nanoparticle (LNP) formulation within the biopharmaceutical industry. The ideal candidate will have practical experience encapsulating nucleic acids, including mRNA, siRNA, or DNA, into LNPs and optimizing formulation processes.

Experience with T-mixer and NanoAssemblr systems is highly preferred. The candidate should also have experience characterizing LNP formulations, analyzing experimental data, and supporting formulation development activities.

Key Responsibilities

• Perform hands-on lipid nanoparticle formulation for nucleic acid delivery applications.
• Encapsulate nucleic acids, including mRNA, siRNA, or DNA, into LNPs.
• Support formulation development, process optimization, and experimental troubleshooting.
• Operate LNP formulation equipment, preferably T-mixer and NanoAssemblr systems.
• Perform LNP characterization and analyze experimental results.
• Document experiments, interpret data, and communicate findings to project teams.
• Follow laboratory procedures and applicable safety and quality practices.

Required Qualifications

• Hands-on LNP formulation experience in the biopharmaceutical industry.
• Practical experience with nucleic acid encapsulation, including mRNA, siRNA, or DNA.
• Experience supporting formulation development or process optimization.
• Ability to work on-site.

Preferred Qualifications

• Experience using T-mixer and NanoAssemblr systems.
• Experience with LNP characterization and data analysis.
• Bachelor's or Master's degree in a relevant scientific discipline preferred.
• PhD candidates with at least one year of hands-on LNP formulation experience may be considered.