Scientist II - LNP Formulation

Tailored Management; San Diego (CA); Sur place; USD 58 000 - 67 000; Plein temps

Avantages offerts par ce poste

Medical Coverage

Dental Insurance

Vision Insurance

Short-Term Disability

Long-Term Disability

Life Insurance

Critical Illness Insurance

EAP

Résumé du poste

Tailored Management in San Diego, CA is seeking a Scientist II to advance lipid nanoparticle formulations for nucleic acid delivery. You will formulate, encapsulate, and characterize LNPs for mRNA, siRNA, or DNA, with DoE-based screening and cross-functional collaboration to accelerate projects.

The role emphasizes hands-on lab work, rigorous data analysis in Excel, and meticulous documentation to ensure reproducibility and quality in a biopharma setting.

Qualifications

• 2+ years in LNP formulation and nucleic acid encapsulation.
• Proficient in DLS, zeta potential and Ribogreen assays.
• Strong DoE experience and data analysis skills.

Responsabilités

• Develop, optimize LNP formulations for nucleic acids.
• Characterize LNPs using DLS, zeta potential and assays.
• Execute DoE-based formulation screening campaigns.
• Support formulation development, scale-up and stability studies.
• Collaborate with cross-functional teams and document results.

Connaissances

LNP Formulation

DLS

Zeta Potential

Ribogreen assay

DoE

Data analysis

Excel proficiency

Formation

Bachelor's degree

Master's degree

Outils

Excel

Description du poste

Scientist II - Lipid Nanoparticle (LNP) Formulation

Work Location: San Diego, CA. 92111

Schedule: Onsite, Mondays to Fridays

Pay Rate: $42.00- $48.28/hour

Position Overview

We are seeking a Scientist II to join our Formulation team, supporting the development and optimization of lipid nanoparticles (LNPs) for nucleic acid delivery. This hands-on laboratory role focuses on the formulation, encapsulation, and characterization of targeted and non-targeted LNPs containing mRNA, siRNA, or DNA for in vitro and in vivo applications.

The successful candidate will execute formulation experiments, conduct Design of Experiments (DoE)-based screening campaigns, analyze experimental data, and collaborate with cross-functional teams to advance non-viral delivery technologies. The ideal candidate has strong technical expertise in LNP formulation, analytical characterization, and experimental data analysis, with a demonstrated ability to produce reproducible results in a biotechnology or pharmaceutical industry setting.

Key Responsibilities

• Lipid Nanoparticle Formulation: Develop, prepare, and optimize targeted and non-targeted lipid nanoparticles (LNPs and tLNPs) for nucleic acid delivery, including mRNA, siRNA, and DNA encapsulation.
• LNP Characterization: Perform physicochemical characterization of LNP formulations using Dynamic Light Scattering (DLS), zeta potential analysis, and Ribogreen assays to evaluate particle size, surface charge, and nucleic acid encapsulation efficiency.
• Design of Experiments (DoE): Execute DoE-based formulation screening campaigns to evaluate lipid compositions, formulation variables, and processing parameters to identify optimal LNP formulations.
• Formulation Development: Support early-stage formulation development, process optimization, and downstream processing activities, including cryoprotection, formulation scale-up, and stability studies.
• Targeted LNP Development: Support the preparation and characterization of targeted LNPs using antibody-based targeting ligands, including monoclonal antibodies (mAbs), Fab fragments, single-chain variable fragments (scFvs), and VHH antibodies.
• Cross-Functional Collaboration: Partner with internal research and development teams to coordinate formulation requests, meet project timelines, and support nucleic acid delivery studies.
• Data Analysis and Reporting: Analyze, interpret, and present formulation and characterization data to the Formulation team. Use Microsoft Excel and applicable statistical analysis software to evaluate experimental results and identify trends.
• Laboratory Documentation: Maintain accurate and detailed laboratory records, experimental protocols, formulation parameters, and results to support data integrity and reproducibility.
• Laboratory Operations: Perform routine laboratory management activities, including inventory tracking, supply ordering, buffer preparation, equipment maintenance, and autoclaving.
• Experimental Optimization: Troubleshoot formulation challenges, refine experimental procedures, and contribute to continuous improvement of LNP preparation and characterization workflows.

Required Qualifications

• Bachelor's degree in chemistry, Biochemistry, Chemical Engineering, Pharmaceutical Sciences, or a related scientific discipline, with at least 5 years of biopharmaceutical industry experience; or
• Master's degree in a related scientific discipline, with at least 2 years of biopharmaceutical industry experience.
• LNP Formulation Experience: Minimum of 2 years of hands-on laboratory experience in lipid nanoparticle formulation and nucleic acid encapsulation, including mRNA, siRNA, or DNA.
• Analytical Characterization: Demonstrated proficiency in LNP characterization techniques, including Dynamic Light Scattering (DLS), zeta potential measurement, and Ribogreen assays.
• Data Analysis: Advanced proficiency in Microsoft Excel for experimental data analysis, organization, and reporting.
• Experimental Design: Familiarity with formulation screening, experimental optimization, and Design of Experiments (DoE) methodologies.
• Laboratory Documentation: Ability to maintain detailed experimental records and generate accurate, reproducible laboratory data.

Benefits

• Medical Coverage – HDHP, PPO, and Surest plan options
• Minimum Essential Coverage (MEC)
• Dental Insurance
• Vision Insurance
• Short-Term Disability (STD)
• Long-Term Disability (LTD)
• Life & AD&D Insurance
• Critical Illness Insurance
• Accident Insurance
• Employee Assistance Program (EAP)