Scientist I

247Hire; California; On-site; USD 90,000 - 130,000; Full time

Job summary

247Hire seeks a Scientist 1 to join the Formulation team. You will execute and optimize the synthesis of lipid nanoparticles (LNPs) for nucleic acid delivery, working with senior scientists in a hands-on laboratory setting.

Responsibilities include DoE-based screening, cross-functional collaboration, and supporting early-stage development with careful data documentation and analysis. A strong background in LNPs and biopharma is required.

Qualifications

• 4+ years of biopharma industry experience or 1+ year with a Master's.
• Hands-on experience in LNP formulation and encapsulation of nucleic acids.
• Experience with LNP characterization methods (DLS, zeta potential, Ribogreen).
• Strong data analysis and documentation skills.

Responsibilities

• Execute and optimize formulation and characterization of LNPs for in vitro/in vivo studies under supervision.
• Implement DoE-based screening campaigns to optimize LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to fulfill formulation requests.
• Support early-stage formulation development including scale-up and stability studies.
• Maintain detailed records of formulation activities and results.
• Analyze, interpret, and present experimental data to the team.
• Contribute to routine lab management including inventory and buffer preparation.

Skills

LNP formulation

Nucleic acid encapsulation

DLS

Zeta potential

Data analysis

MS Excel

Cross-functional collaboration

Education

Bachelor's degree in Chemistry/Biochemistry/Chemical Engineering or related

Tools

JMP

Prism

Job description

Responsibilities:

Seeking a motivated and detail-oriented Scientist 1 to join our Formulation team. In this hands-on laboratory role, you will work closely with senior scientists to execute and optimize the synthesis of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery. The successful candidate will be a collaborative team player with strong technical and data analysis skills who is ready to contribute to our non-viral delivery platform.

• Execute and optimize the formulation and characterization of lipid nanoparticles (LNPs) or targeted lipid nanoparticle (tLNPs) encapsulating nucleic acids for in vitro and in vivo studies under the minor guidance of senior formulation scientists.
• Implement Design of Experiment (DoE) based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to support and fulfill formulation requests.
• Support early-stage formulation development and downstream processing activities when needed, including cryoprotection, scale-up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management activities, including inventory tracking, supply ordering, buffer preparation, and autoclaving.

Required Skills:

• Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 4+ years of biopharma industry experience, OR a Master's degree with 1+ years of industry experience.
• LNP Expertise: Minimum of 2 years of hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Analytical Skills: Proficiency with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
• Software & Data: High proficiency in MS Excel is required; hands-on experience with statistical and data analysis software (e.g., JMP, Prism) is preferred.
• Core Competencies: Strong attention to detail, a track record of producing reproducible data, excellent organizational skills, and the ability to communicate effectively within a fast-paced team environment.

Preferred Skills:

• Prior experience with targeted LNP preparation (mAb, Fab, ScFv, VHH coated LNP) and immune cell delivery is highly desirable.