Scientist II - LNP Formulation

247Hire; San Diego (CA); On-site; USD 120,000 - 170,000; Full time

Job summary

247Hire is seeking a Scientist to join the Formulation team in San Diego. This hands-on role focuses on synthesizing and optimizing lipid nanoparticles for nucleic acid delivery, working closely with senior scientists to advance our non-viral delivery platform.

You will perform DoE-based screening to optimize LNP compositions, collaborate across teams, document results meticulously, and contribute to early-stage formulation development, stability studies, and routine lab management.

Qualifications

• Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 5+ years of biopharma industry experience, OR a Master's degree with 2+ years of industry experience.
• LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA) with 2+ years hands-on laboratory experience.
• Proficiency with LNP characterization methods: DLS, zeta potential, and Ribogreen assays.
• High proficiency in MS Excel.
• Strong attention to detail, reproducible data, and organizational skills.

Responsibilities

• Execute and optimize formulation and characterization of LNPs or tLNPs encapsulating nucleic acids for in vitro and in vivo studies.
• Implement DoE-based screening campaigns to optimize LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to fulfill formulation requests.
• Support early-stage formulation development, including cryoprotection, scale-up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management: inventory, supplies, buffer prep, and autoclaving.

Skills

LNP formulation

Data analysis

MS Excel

Detail oriented

Team communication

Laboratory collaboration

Education

Bachelor's degree in Chemistry/Biochemistry/Chemical Engineering

Tools

Dynamic Light Scattering (DLS)

Zeta potential

RiboGreen assay

JMP

Prism

Job description

Responsibilities :
Seeking a motivated and detail-oriented Scientist to join our Formulation team. In this hands-on laboratory role, you will work closely with senior scientists to execute and optimize the synthesis of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery. The successful candidate will be a collaborative team player with strong technical and data analysis skills who is ready to contribute to our non-viral delivery platform.

• Execute and optimize the formulation and characterization of lipid nanoparticles (LNPs) or targeted lipid nanoparticle (tLNPs) encapsulating nucleic acids for in vitro and in vivo studies under the minor guidance of senior formulation scientists.
• Implement Design of Experiment (DoE) based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to support and fulfill formulation requests.
• Support early-stage formulation development and downstream processing activities when needed, including cryoprotection, scale-up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management activities, including inventory tracking, supply ordering, buffer preparation, and autoclaving

Required Skills:

• Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 5+ years of biopharma industry experience, OR a Master's degree with 2+ years of industry experience.
• LNP Expertise: Minimum of 2 years of hands‑on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Analytical Skills: Proficiency with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
• Software & Data: High proficiency in MS Excel is required
• Core Competencies: Strong attention to detail, a track record of producing reproducible data, excellent organizational skills, and the ability to communicate effectively within a fast‑paced team environment.

Preferred Skills:

• Prior experience with targeted LNP preparation (mAb, Fab, ScFv, VHH coated LNP) and immune cell delivery is highly desirable.
• Hands‑on experience with statistical and data analysis software (e.g., JMP, Prism) is preferred.