Scientist II, Advanced In Vitro Modeling

Allergan; Worcester (MA); On-site; USD 100,000 - 140,000; Full time

Benefits offered by this job

Paid time off

Medical/dental/vision insurance

401(k)

Job summary

AbbVie Immunology is seeking a scientist to design, execute, and interpret in vitro studies that characterize drug candidates and validate targets using primary human cells and complex 3D systems such as organoids or organ-on-chip models.

You'll design experiments, analyze data, and present findings, while maintaining accurate records and applying assays like ELISA, flow cytometry, and high-content imaging to support discovery programs in a fast-paced, collaborative environment.

Qualifications

• BS or MS in Biological science with focus in Immunology, Biochemistry, Molecular Biology, Cell Biology, or related with typically 7+ (BS) or 5+ (MS) years of relevant lab experience.
• Proficiency in culturing primary human immune cells, immortalized cell lines, and organ/tissue cultures, incl. iPSCs, using standard tissue culture and transwell systems.
• Experience developing and applying complex in vitro models, incl. co-culture and advanced 3D cellular systems, to support discovery programs.
• Experience designing experiments to study cell signaling, phosphoproteins, second messenger pathways, cell proliferation, gene reporter assays, and soluble mediator release.
• Demonstrated motivation, strong attention to detail, scientific curiosity, and eagerness to learn novel in vitro pharmacology techniques.

Responsibilities

• Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human cells, cell lines and complex in vitro systems such as organoids or organ-on-chip models.
• Analysis, interpret and clearly communicate quantitative data.
• Conduct and organize activities and communicate through oral and written presentations.
• Read and apply relevant scientific literature.
• Maintenance of accurate and current records of research.

Skills

Immunology expertise

Lab techniques

Data analysis

Attention to detail

Collaboration

Education

BS/MS in Biological sciences

Tools

ELISA

Flow cytometry

PCR

GraphPad Prism

Excel

Job description

AbbVie Immunology is seeking a scientist to design, execute, and interpret in vitro studies that characterize drug candidates and validate targets using primary human cells and complex 3D systems such as organoids or organ-on-chip models.

You'll design experiments, analyze data, and present findings, while maintaining accurate records and applying assays like ELISA, flow cytometry, and high-content imaging to support discovery programs in a fast-paced, collaborative environment.