Scientist II, Complex In Vitro Model

Initial Therapeutics, Inc.; Massachusetts; On-site; USD 110,000 - 160,000; Full time

Job summary

AbbVie Immunology is seeking a scientist to support the design, execution, and interpretation of in vitro studies on drug candidates and targets. The role involves using primary human cells and advanced 3D systems to characterize potency and mechanism of action across immunology projects.

Responsibilities include data analysis, presenting results, literature appraisal, and meticulous record-keeping to ensure rigorous scientific progress in a fast-paced, cross-functional team.

Qualifications

• BS or MS in Biological science with a focus on Immunology, Biochemistry, Molecular Biology or Cell Biology.
• Typically 7+ years (BS) or 5+ years (MS) of relevant lab experience.
• Experience culturing primary human immune cells and organ/tissue cultures.
• Experience with complex in vitro models, including 3D cultures.

Responsibilities

• Design and perform biochemical and cellular studies of drug potency and mechanism using primary human cells and organoid/organ-on-chip systems.
• Analyze, interpret and clearly communicate quantitative data.
• Conduct and organize activities and present orally and in writing.
• Read and apply relevant scientific literature to project work.
• Maintain accurate, current records of research activities.

Skills

In vitro pharmacology

3D cell culture

Scientific data analysis

Oral & written communication

Education

BS or MS in Biological science (Immunology/Biochemistry/Molecular Biology)

Tools

ELISA/MSD

AlphaLISA

HTRF

PCR

Flow cytometry

High content microscopy

GraphPad Prism

Excel

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, XandYouTube.

Job Description

AbbVie Immunology is dedicated to discovering breakthrough therapies for inflammatory and auto-immune diseases that can meaningfully improve patients lives. The Complex In Vitro Model group is seeking a scientist to support the design, execution, and interpretation of in vitro studies on the characterization of drug candidate molecules and the validation of drug targets.

Key Responsibilities

• Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human blood cells, cell lines and complex in vitro systems such as organoids or organ-on-chip models.
• Analysis, interpret and clearly communicate quantitative data.
• Conduct and organize activities and communicate through oral and written presentations.
• Read and apply relevant scientific literature.
• Maintenance of accurate and current records of research.

Qualifications

• BS or MS in Biological science with focus in Immunology, Biochemistry, Molecular Biology, Cell Biology, or a related discipline with typically 7+ (BS) or 5+ (MS) years of relevant lab experience.
• Proficiency in culturing primary human immune cells, immortalized cell lines, and organ/tissue cultures, including differentiated cells and iPSCs, using standard tissue culture and transwell systems.
• Experience developing and applying complex in vitro models, including co-culture and advanced 3D cellular systems, to support discovery programs.
• Experience designing experiments to study cell signaling, phosphoproteins, second messenger pathways, cell proliferation, gene reporter assays, and soluble mediator release.
• Expertise in ELISA/MSD, alphaLISA, HTRF, PCR, multicolor flow cytometry, high content microscopy, and related methodologies.
• Demonstrated motivation, strong attention to detail, scientific curiosity, and eagerness to learn novel in vitro pharmacology techniques.
• Strong background in statistics with proficiency in spreadsheets and curve-fitting software such as Microsoft Excel and GraphPad Prism.
• Skilled in leveraging automation to increase assay robustness, improve throughput, and enable miniaturization of experimental workflows.
• Highly collaborative and able to thrive in a fast-paced, cross-functional, multidisciplinary environment, with strong organizational, communication, and interpersonal skills.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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