Scientist, II

BioSpace; Worcester (MA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Competitive benefits package

Job summary

AbbVie’s GI/Immunology Discovery Research group seeks a skilled pharmacologist to lead in vivo and in vitro studies of inflammatory GI disorders. You will drive assay development, design animal studies, and analyze data to advance programs toward the clinic.

The role emphasizes hands-on wet lab work, data presentation, and collaboration with cross-functional teams while requiring strong communication and leadership in scientific forums.

Qualifications

• Bachelor’s degree or higher with relevant experience in GI pharmacology.
• Experience with in vitro and in vivo cell killing endpoints preferred.
• Proficiency in primary cell culture and handling human/rodent cells.

Responsibilities

• Design, execute and analyze in vivo pharmacology studies in GI models.
• Perform in vitro assays and data interpretation for test articles.
• Prepare regulatory documents and communicate results to teams.

Skills

In vivo pharmacology

In vitro pharmacology

Primary cell culture

RT-qPCR

Western blot

Flow cytometry

Mouse models

Human tissue handling

Education

Bachelor’s Degree or equivalent education

Master’s Degree or equivalent education

Tools

RT-qPCR

Western blot

Multi-parameter flow cytometry

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

AbbVie’s Gastrointestinal(GI)/Immunology Discovery Research group is looking for a highly motivated and experienced in vivo and in vitro pharmacologist to play an integral role in advancing therapeutics to treat inflammatory GI disorders. This position offers an exciting opportunity to understand the pharmacodynamic effects of experimental medicines with GI relevant in vitro and in vivo assays.

The ideal candidate would work within the highly matrixed and collaborative Discovery Immunology team to guide test article screening and assay development as well as build biology packages for early stage programs. Experimental focus will be on developing and leveraging in vivo and in vitro systems to help understand the impact of test articles in mucosal immunity. The candidate is expected to design, execute, interpret and present innovative research to advance programs towards the clinic. We are seeking a hands‑on experimentalist who is proficient with in vivo and in vitro cell biology research and has demonstrated scientific leadership with internal and external stake holders/experts. The expectation is that the candidate would dedicate the majority of their time toward wet lab experimentation, data analysis and presentation. In addition, we are seeking a candidate with excellent written and oral communication skills. The candidate will have the opportunity to present their results at team and internal/external science meetings. Prior technical experience in IBD mouse models, humanized mice, biologics molecule screening, and handling of human tissue are required.

Major Responsibilities

• Highly autonomous and productive in performing laboratory research and method development, requiring only minimal direction from supervisor
• Execute on discovery screening funnels for novel test articles
• Design, execute and analyze in vivo pharmacology studies in colitis or other GI mouse models
• Prepare and execute experiments with human blood or intestinal tissue
• Formulate conclusions and design follow‑on experiments based on multidisciplinary data
• Primary author of regulatory documents
• Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, and animal care

Qualifications

• Bachelor’s Degree or equivalent education and typically, 7 years of work experience, Master’s Degree or equivalent education and typically 5 years of work experience
• Experience with in vitro and in vivo cell killing endpoints preferred
• Highly proficient in primary cell culture, including isolation of human and rodent cells and activation with inflammatory stimulation is preferred
• Experience with ex vivo intestinal tissue assays
• Possess thorough theoretical and practical understanding of own scientific discipline, especially within gastrointestinal physiology and inflammation.
• Highly proficient and efficient with in vivo techniques such as mouse restraint, PO, RO and IP dosing routes, and rodent necropsy. Experience with some colitis models or humanize mouse models is required.
• Technical capabilities including RT-qPCR, Western blot, multi-parameter flow cytometry
• Demonstrated ability to learn, understand and master new experimental techniques.
• Demonstrated scientific writing skills and strong verbal communication skills through publication and conference presentations.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html