Scientist, II

ABBVIE; Worcester (MA); On-site; USD 85,000 - 162,000; Full time

Job summary

AbbVie’s Gastrointestinal/Immunology Discovery Research group seeks an experienced invivo and in vitro pharmacologist to advance therapies for inflammatory GI disorders. The role focuses on PD effects of experimental medicines using GI-relevant assays.

The candidate will design, execute, and interpret studies in colitis and humanized mouse models, lead data analysis, and present findings to internal teams and stakeholders.

Qualifications

• Bachelor’s or master’s degree with bench experience in GI/inflammation biology
• Experience with in vivo GI mouse models and human tissue handling
• Strong experimental design and data interpretation skills

Responsibilities

• Design, execute and analyze in vivo pharmacology studies in colitis or GI mouse models
• Perform in vitro assays and work with human tissue samples
• Lead data analysis, formulate conclusions and present results to teams and stakeholders
• Prepare and contribute to regulatory documents
• Communicate findings effectively at internal/external meetings

Skills

In vivo pharmacology

In vitro pharmacology

Scientific leadership

Verbal communication

Education

Bachelor’s Degree or equivalent

Master’s Degree or equivalent

Tools

RT-qPCR

Western blot

Flow cytometry

Job description

• Compensation: USD 84500 - USD 162000 - yearly

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com . Follow @abbvie onLinkedIn, Facebook ,Instagram ,X andYouTube.

Job Description

AbbVie’sGastrointestinal(GI)/Immunology Discovery Research group is looking for a highly motivated andexperienced invivo and in vitropharmacologistto play an integral role inadvancing therapeuticsto treat inflammatory GI disorders.This position offers an exciting opportunity tounderstand thepharmacodynamic effectsof experimental medicineswith GI relevant in vitro and in vivo assays.

The ideal candidate would work within the highly matrixed and collaborativeDiscovery Immunologyteam toguidetest articlescreening and assay development as well asbuild biology packages forearly stageprograms.Experimental focus will be ondeveloping andleveragingin vivo and in vitro systems tohelpunderstand the impact of test articlesinmucosal immunity.The candidate is expected to design, execute,interpretand present innovative research to advance programstowards the clinic.We are seeking a hands-on experimentalist who isproficientwithin vivo and in vitrocell biology research andhasdemonstratedscientificleadership withinternal and externalstake holders/experts.The expectation is that the candidate would dedicatethe majority oftheir time toward wet lab experimentation, dataanalysisand presentation.In addition, we are seeking a candidatewith excellent written and oral communication skills.The candidate will have the opportunity to present their results at team and internal/external science meetings.Priortechnicalexperience inIBDmouse models, humanized mice,biologicsmolecule screening, and handling of human tissuearerequired.
Major Responsibilities:

Highly autonomous and productive in performing laboratory research and method development, requiring only minimal direction from supervisor

Execute ondiscovery screening funnels fornovel test articles

Design, execute and analyze in vivopharmacologystudies in colitis or other GI mouse models

Prepareand execute experiments withhuman blood or intestinal tissue

Formulate conclusions and design follow-on experiments based on multidisciplinary data

Primary author of regulatory documents.

Understand and adhere to corporate standardsregardingcode of conduct, safety,appropriate handlingof materials, controlled drug and radioactive compounds, and animal care

Qualifications

Bachelor’s Degree or equivalent education and typically,7years ofworkexperience,Master’s Degreeor equivalent education and typically5years of work experience

Experiencewithin vitro and in vivocell killingendpoints preferred

Highly proficient in primary cell culture, including isolation of human and rodent cells and activation with inflammatory stimulationis preferred

Experience with ex vivo intestinal tissue assays

Possess thorough theoretical and practical understanding ofownscientific discipline, especially within gastrointestinal physiology and inflammation.

Highly proficientand efficientwithin vivo techniques such as mouse restraint, PO, ROand IP dosing routes, and rodent necropsy.Experience with some colitis modelsor humanize mouse modelsisrequired.

Technical capabilities including RT-qPCR,Westernblot,multi-parameterflowcytometry

Demonstrated ability to learn,understandand master new experimental techniques.

Demonstrated scientific writing skills and strong verbal communication skillsthrough publication and conference presentations.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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