Scientist II, Complex In Vitro Model

BioSpace; Worcester (MA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Paid time off

Medical/Dental/Vision

401(k)

Job summary

AbbVie Immunology seeks a scientist to support design, execution, and interpretation of in vitro studies for drug candidate characterization and target validation. The role emphasizes organoid/3D systems, primary human cells, and advanced immunoassays in a collaborative setting.

The candidate will design experiments, analyze data, and communicate results clearly while maintaining meticulous records in a fast-paced environment. Strong technical writing and presentation skills are essential.

Qualifications

• BS or MS in Biological science with Immunology/Biochemistry/Molecular Biology focus; typically 7+ (BS) or 5+ (MS) years of relevant lab experience.
• Proficiency in culturing primary human immune cells, immortalized cell lines, organ/tissue cultures, including iPSCs.
• Experience developing and applying complex in vitro models (co-culture, 3D systems) for discovery programs.
• Experience designing experiments for cell signaling, phosphoproteins, second messenger pathways, cell proliferation and reporter assays.
• Expertise in ELISA/MSD, alphaLISA, HTRF, PCR, multicolor flow cytometry, high content microscopy.
• Strong attention to detail, scientific curiosity and eagerness to learn new techniques.
• Statistical proficiency with Excel and GraphPad Prism; comfortable with data interpretation and presentation.
• Experience leveraging automation to increase throughput and miniaturize workflows.
• Highly collaborative, cross-functional, and able to communicate effectively.

Responsibilities

• Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human cells and advanced in vitro systems.
• Analyze, interpret and clearly communicate quantitative data.
• Conduct and present findings through oral and written presentations.
• Read and apply relevant scientific literature; maintain accurate research records.

Skills

In Vitro Pharmacology

Cell Culture

3D Models

Biochemical & Cellular Assays

Data Analysis & Statistics

Immunoassays (ELISA/ MSD)

Flow Cytometry & HCS

Scientific Communication

Automation & Throughput

Team Collaboration

Education

BS or MS in Biological Science

Tools

Excel

GraphPad Prism

Transwell Systems

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

AbbVie Immunology is dedicated to discovering breakthrough therapies for inflammatory and auto-immune diseases that can meaningfully improve patients’ lives. The Complex In Vitro Model group is seeking a scientist to support the design, execution, and interpretation of in vitro studies on the characterization of drug candidate molecules and the validation of drug targets.

Key Responsibilities

• Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human blood cells, cell lines and complex in vitro systems such as organoids or organ-on-chip models.
• Analysis, interpret and clearly communicate quantitative data.
• Conduct and organize activities and communicate through oral and written presentations.
• Read and apply relevant scientific literature.
• Maintenance of accurate and current records of research.

Qualifications

• BS or MS in Biological science with focus in Immunology, Biochemistry, Molecular Biology, Cell Biology, or a related discipline with typically 7+ (BS) or 5+ (MS) years of relevant lab experience.
• Proficiency in culturing primary human immune cells, immortalized cell lines, and organ/tissue cultures, including differentiated cells and iPSCs, using standard tissue culture and transwell systems.
• Experience developing and applying complex in vitro models, including co-culture and advanced 3D cellular systems, to support discovery programs.
• Experience designing experiments to study cell signaling, phosphoproteins, second messenger pathways, cell proliferation, gene reporter assays, and soluble mediator release.
• Expertise in ELISA/MSD, alphaLISA, HTRF, PCR, multicolor flow cytometry, high content microscopy, and related methodologies.
• Demonstrated motivation, strong attention to detail, scientific curiosity, and eagerness to learn novel in vitro pharmacology techniques.
• Strong background in statistics with proficiency in spreadsheets and curve-fitting software such as Microsoft Excel and GraphPad Prism.
• Skilled in leveraging automation to increase assay robustness, improve throughput, and enable miniaturization of experimental workflows.
• Highly collaborative and able to thrive in a fast-paced, cross-functional, multidisciplinary environment, with strong organizational, communication, and interpersonal skills.

Additional Information

• Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.
• Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
• AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
• US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html