Scientist I/II, in vivo pharmacology

Amplitude Therapeutics; Boston (MA); On-site; USD 75,000 - 110,000; Full time

Job summary

Amplitude Therapeutics in Boston Seaport seeks an experienced Scientist I/II to lead in vivo studies across vaccines and in vivo models, including coordination with CROs. The role blends hands-on work (50–75%) with internal project management and external stakeholder collaboration.

The ideal candidate has strong mouse study design/execution experience and exposure to in vivo pharmacology for large molecule programs, with flexibility for site visits at the Cambridge vivarium and Seaport campus.

Qualifications

• BS/MS/PhD with relevant industry experience (10+/6+/2+ yrs) as applicable.
• Hands-on vaccine, CAR, or mAb/TCE rodent experiments required.
• Dosing methods (IV/SC/IM/IP), blood collection, necropsy & tissue collection.
• Experience with data analysis software and ELISA/ELISpot assays.
• CRO management and IACUC protocol experience preferred.

Responsibilities

• Lead execution of in vivo experiments with an emphasis on vaccine studies.
• Own the study strategy, design, and execution, coordinating with internal team members and CROs.
• Conduct in vivo studies including dosing, blood collection, necropsy, and tissue collection.
• Assist downstream assays such as ELISAs, ELISpots, and MSD/Luminex.
• Willingness to conduct experiments at vivarium (Cambridge, MA) and Amplitude’s Seaport site.

Skills

Vaccine studies

CAR studies

MAb/TCE rodent experiments

Study design

Data analysis

Verbal and written communication

Project management

CRO management

IACUC protocols

Flexibility

Education

BA/MS/PhD in life sciences

Tools

ELISAs

ELISpots

MSD/Luminex

GraphPad Prism

Microsoft Office

Job description

Amplitude Therapeutics is a seed-stage biotechnology company focusing on developing the next generation of RNAs to fully unlock the therapeutic potential of RNA biology. We were founded by leaders in the RNA and non-viral therapy fields and backed by premier Biotech VCs. Amplitude is located in the Boston Seaport.

Position Summary:

We are seeking a highly motivated and experienced Scientist I/II to join our in vivo function at Amplitude Therapeutics. At Amplitude, we conduct in vivo experiments across various applications (e.g. vaccines and in vivo CAR) and in vivo models (rodents and NHPs).

Working with a high degree of independence and reporting to the CEO, this role will oversee and directly execute ~5 in vivo studies per month which are conducted at an off-site vivarium (in Cambridge). You will also coordinate various rat and NHP experiments conducted at CROs.

This role blends hands‑on execution (approximately 50-75% of the role) with the management of internal projects and external stakeholders (e.g. partners and CROs). The ideal candidate is an experienced, hands‑on in vivo scientist with a strong foundation in mouse study design and execution. The ideal candidate will have hands‑on experience with the in vivo pharmacology aspects for a large molecule program (e.g. mAb, siRNA, mRNA, recombinant protein).

The right candidate will be enthusiastic about directly contributing to the development of meaningful medicines by efficiently and effectively advancing pre‑clinical studies. You will joining a high-achieving, focused team and will have the chance to meaningfully contribute to the work at Amplitude.

Responsibilities:

• Lead the execution of in vivo experiments with an emphasis on vaccine studies.
• Own the implementation of the study strategy, design, and execution of those in vivo studies, coordinating with internal team members on experimental design, logistics, animal ordering and handling, and downstream assays.
• Conduct in vivo studies (e.g. dosing, blood collection, necropsy, and tissue collection) to support the in vivo study schedule.
• Assist in the execution of downstream assays including ELISAs, ELISpots, and MSD / Luminex.
• Willingness and ability to conduct experiments at vivarium (Cambridge, MA) and Amplitude’s main site (Seaport).

Qualifications:

• B.A., M.S. or Ph.D. with 10+, 6+, or 2+ years of relevant industry experience, respectively.
• Hands‑on expertise in conducting vaccine, CAR, or mAb/TCE-based rodent experiments is required.
• Skilled in various methods of dosing (IV, SC, IM, and IP), blood collection (tail vein/submandibular/cardiac puncture) and collection of multiple tissues at necropsy.
• Familiarity with software such as GraphPad Prism, Microsoft Office, and electronic laboratory notebooks for data analysis and reporting.
• CRO management experience and IACUC protocol experience are preferred.
• Highly motivated and able to be flexible in case of changing priorities.
• Effective verbal and written communication skills.