Scientist I, Formulation Development

Scorpion Therapeutics; San Diego (CA); Hybrid; USD 90,000 - 120,000; Full time

Job summary

Avidity Biosciences is seeking a Scientist I in Analytical and Formulation to advance clinical and commercial formulation development of RNA therapeutics, including AOCs. The role emphasizes stability studies, analytical characterization, and collaboration with partners.

The successful candidate will design experiments, interpret data, and contribute to development strategies while working in a hybrid setup in San Diego, CA, with remote options.

Qualifications

• PhD in chemistry, biology, pharmaceutical sciences, or related field.
• Hands-on experience with analytical and biophysical characterization of biologics.
• Proficiency in formulation study design (DOE).
• Proficiency with JMP for data analysis and design of experiments.
• Strong communication and teamwork skills.

Responsibilities

• Design and execute stability and in-use compatibility studies for mAb and AOC liquid and lyophilized forms.
• Support developability assessments of early-stage biologics.
• Perform routine laboratory tasks.
• Collaborate with vendors.
• Support process development activities.
• Train personnel.
• Manage instrumentation.
• Document data and present findings.

Skills

Biologics characterization

Formulation study design

Communication & teamwork

DOE

JMP

Analytical techniques

Education

PhD in chemistry/biology/pharmaceutical sciences

Tools

SEC

IEX

RP-HPLC

CE-SDS

cIEF

Light scattering

JMP

Job description

Role: Scientist I in Analytical and Formulation at Avidity Biosciences, focusing on clinical and commercial formulation development of RNA Therapeutics, specifically Antibody Oligonucleotide Conjugates (AOCs).

Responsibilities

• design and execute stability and in-use compatibility studies for mAb and AOC liquid and lyophilized forms;
• support developability assessments of early-stage biologics;
• perform routine laboratory tasks;
• collaborate with vendors;
• support process development activities;
• train personnel;
• manage instrumentation;
• document data;
• present findings.

Requirements

• PhD in chemistry, biology, pharmaceutical sciences, or related field;
• hands-on experience with analytical and biophysical characterization of biologics including SEC, IEX, RP-HPLC, CE-SDS, cIEF, light scattering;
• proficiency in formulation study design (DOE, JMP);
• strong communication and teamwork skills.

Preferred

familiarity with mass spectrometry for mAb stability and ADC characterization, lyophilization, oligonucleotide chemistry, working with CMOs/CROs, managing direct reports.

HighValue

biologics (mAbs, ADCs), RNA therapeutics (AOCs), formulation development, stability testing, analysis of protein stability, hybrid work setup in San Diego, CA, with remote options.