Formulation Scientist I, RNA Therapeutics

Avidity Biosciences, Inc.; San Diego (CA); On-site; USD 99,750 - 110,250; Full time

Benefits offered by this job

Annual bonus

401(k) match

Wellness program (medical, dental, VIs

Four weeks of time off

Education reimbursement

Job summary

Avidity Biosciences, Inc. in San Diego, CA, is seeking an Associate Scientist I to join the Analytical Development & Formulation group.

The role focuses on clinical and commercial formulation development of AOC drug products and drug substance, with duties spanning developability assessments and in-use compatibility studies for IV/SC routes. Ideal candidates have strong analytical/biophysical characterization experience (SEC, IEX, RP-HPLC, CE-SDS, cIEF) and a background in protein biologics

Qualifications

• A bachelor’s degree (or master’s) in chemistry, biology, pharmaceutical sciences, or a related field with a minimum of 5 years of industrial experience (3 years for a master’s degree).
• Experience in protein stability and degradation pathways particularly for mAb.
• Experience setting up formulation development and in-use compatibility studies.
• Hands-on with analytical methods including SEC, IEX, RP-HPLC, CE-SDS, cIEF and subvisible particle analysis.
• Biophysical methods for conformational and colloidal stability like DSC, DLS, and SLS.
• Ability to multi-task in a fast-paced cross-functional environment.
• Excellent communication, teamwork, and problem-solving skills.

Responsibilities

• Set up and conduct formulation stability studies for mAb and AOC dosage forms.
• Perform developability assessments of early-stage protein biologics.
• Prepare buffers, manage lab inventory, and coordinate instrument maintenance with vendors.
• Conduct in-use compatibility studies for IV and SC administration routes.
• Support drug substance/product development activities as needed.
• Provide hands-on lab support to biology and chemistry teams with analytical characterization.
• Specify, purchase, and install formulation-related instrumentation and equipment.
• Maintain electronic lab notebooks and write technical reports.
• Present data at team and cross-functional meetings.
• Contribute to agile, integrated, and diverse company values.

Skills

Formulation development

Biophysical characterization

Stability testing

Cross-functional collaboration

Data processing

Documentation

Vendor coordination

Instrumentation setup

Presentation

Education

Bachelor's degree in chemistry/biology or related field

Master's degree in related field

Tools

SEC

IEX

RP-HPLC

CE-SDS

cIEF

Subvisible particle analysis

Differential scanning calorimetry

Dynamic light scattering

Mass spectrometry

Lyophilization

Job description

Avidity Biosciences, Inc. in San Diego, CA, is seeking an Associate Scientist I to join the Analytical Development & Formulation group.

The role focuses on clinical and commercial formulation development of AOC drug products and drug substance, with duties spanning developability assessments and in-use compatibility studies for IV/SC routes. Ideal candidates have strong analytical/biophysical characterization experience (SEC, IEX, RP-HPLC, CE-SDS, cIEF) and a background in protein biologics