Scientist, High-Throughput Protein Expression and Purification

Bristol-Myers Squibb; United States; On-site; USD 110,000 - 170,000; Full time

Benefits offered by this job

Comprehensive benefits

Health and welfare programs

Tuition assistance

Job summary

Bristol Myers Squibb is seeking a highly motivated Scientist to expand high-throughput biologics production capabilities within Discovery Biotherapeutics. The role focuses on scalable protein expression, purification, normalization, and characterization for antibody and multispecific biologics programs.

The candidate should have practical mammalian protein production experience, the ability to independently run experiments, analyze data, troubleshoot workflows, and deliver high-quality reagents.

Qualifications

• Bachelor's degree in biochemistry, bioengineering, structural biology, molecular biology, or related field with 5+ years experience; or Master's with 3+ years; or PhD with no additional experience.
• Hands-on protein expression and production workflows in mammalian systems.
• Experience with transient mammalian expression using HEK293, CHO, or related systems.
• Experience with purification technologies including affinity chromatography and quality assessment methods.
• Molecular biology background with cloning and high-throughput DNA fragment generation.
• Ability to design/execute experiments, analyze data, troubleshoot, and document.
• Ability to manage evolving priorities in a matrixed environment.
• Strong communication and collaboration; uphold lab safety and data integrity.

Responsibilities

• Execute high-throughput protein production workflows supporting antibody and other biologics discovery programs.
• Design, optimize, and troubleshoot transient mammalian expression workflows at micro- and mid-scale in HEK293/CHO systems.
• Perform automated protein purification, normalization, and quality assessment to deliver protein reagents.
• Operate and maintain liquid handlers, robotics, automated purification systems, and related instrumentation.
• Develop scalable workflows for expression, purification, normalization, and QC.
• Plan/execute experiments, analyze data, document results, communicate to cross-functional teams.
• Coordinate with Protein Sciences, Molecular Biology, Automation, Data Science, and Discovery Biology teams.
• Evaluate emerging technologies and miniaturization to improve throughput and reliability.
• Establish SOPs, quality standards, and data integrity practices.
• Lead/root-cause analysis for workflow/instrumentation issues; implement corrective actions.
• Drive continuous-improvement to reduce cycle time and expand platform capabilities.

Skills

High-throughput workflows

Mammalian expression

Protein purification

Automation experience

Data analysis

Troubleshooting

Cross-functional collaboration

Experimental design

Education

Bachelor's degree (Biochemistry/Bioengineering/related)

Master's degree or PhD (optional)

Tools

HEK293/CHO cell systems

Automated purification systems

Laboratory automation equipment

Job description

At Bristol Myers Squibb, our employees often ask, \"Who are you working for?\"-a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Position Summary

We are seeking a highly motivated Scientist to expand high-throughput biologics production capabilities within Discovery Biotherapeutics. This hands-on, laboratory-facing role will execute and advance scalable protein expression, purification, normalization, and characterization workflows that enable antibody, multispecific, and other biologics discovery programs. The successful candidate will bring practical experience in mammalian protein production and protein purification, with the ability to independently execute experiments, analyze data, troubleshoot workflows, and deliver high-quality protein reagents. The Scientist will work closely with Protein Sciences, Molecular Biology, Automation, Data Science, Discovery Biology, and project teams to align production activities with program priorities and experimental timelines. The ideal candidate thrives in a fast-paced, collaborative environment, enjoys solving technical challenges, and is motivated to apply automation and emerging technologies to improve throughput, reproducibility, and cycle time. Experience with laboratory automation, cell-free expression, workflow scripting, or closed-loop discovery is preferred.

Key Responsibilities

• Execute high-throughput protein production workflows supporting antibody, multispecific, and other biologics discovery programs.
• Design, optimize, and troubleshoot transient mammalian expression workflows at micro- and mid-scale using HEK293, CHO, or related systems.
• Perform automated and semi-automated protein purification, sample normalization, and quality assessment to deliver fit-for-purpose protein reagents and therapeutic molecules.
• Operate, maintain, troubleshoot, and continuously improve liquid handlers, robotic workstations, automated purification systems, and associated analytical instrumentation.
• Develop robust, reproducible, and scalable workflows for protein expression, purification, normalization, and quality control.
• Plan and execute experiments, analyze and interpret scientific and operational data, document results, and communicate findings to cross-functional teams and project stakeholders.
• Partner with Protein Sciences, Molecular Biology, Automation, Data Science, Discovery Biology, and project teams to coordinate production requirements, priorities, and timelines.
• Evaluate and implement emerging technologies, instrumentation, miniaturization strategies, and automation solutions that improve throughput, quality, reproducibility, and operational efficiency.
• Establish and maintain best practices, standard operating procedures, quality standards, and documentation that support data integrity, reproducibility, and safe laboratory operations.
• Lead or contribute to root-cause analysis and resolution of workflow, production, and instrumentation issues, and implement corrective and preventive actions.
• Drive continuous-improvement initiatives that reduce cycle time, increase workflow reliability, and expand platform capabilities.

Required Qualifications & Experience

• Bachelor's degree in biochemistry, bioengineering, structural biology, molecular biology, or a related scientific discipline with 5 or more years of relevant academic and/or industry experience; or a master's degree with 3 or more years of relevant experience; or a Ph.D. with no additional experience required.
• Hands-on experience with protein expression and production workflows in mammalian systems.
• Working knowledge of transient mammalian expression using HEK293, CHO, or related cell systems.
• Experience with protein purification technologies, including affinity chromatography, and with protein quality assessment methods.
• Molecular biology background, with a strong understanding of cloning and high-throughput DNA fragment generation.
• Ability to independently design and execute experiments, analyze data, troubleshoot technical problems, maintain accurate documentation, and advance assigned work.
• Ability to manage evolving priorities and timelines in a collaborative, matrixed research environment.
• Strong communication, collaboration, organizational, and problem-solving skills, with a clear commitment to laboratory safety and data integrity.

Preferred Qualifications

• Experience executing high-throughput or plate-based protein expression, purification, normalization, and quality-control workflows across multiple concurrent requests or programs.
• Experience operating, maintaining, or troubleshootin