Scientist, Genome Sciences & Engineering

Stylus Medicine, Inc.; Cambridge (MA); On-site; USD 125,000 - 140,000; Full time

Job summary

Stylus Medicine, Inc. in Cambridge, MA is seeking a Scientist to advance in vitro functional assessment of lead genome editors, supporting translational and preclinical development.

You will develop assays (ddPCR, qPCR), work with primary human cells, and collaborate across R&D to push genome editing platforms toward clinical programs.

Qualifications

• PhD or equivalent with strong background in cell biology or molecular biology.
• Hands-on experience with LNP delivery and primary cell culture.
• Experience with genome editing and related assays.

Responsibilities

• Design and execute in vitro functional assays for candidate selection and preclinical development.
• Develop and optimize ddPCR/qPCR and cytogenetic assays to measure editor activity and biodistribution.
• Support genome editor engineering campaigns by running high-throughput screens in relevant cell lines.
• Troubleshoot experiments, analyze data, and translate results into actionable insights.
• Maintain detailed notebooks and communicate findings to the team.
• Collaborate across R&D to advance candidates into translational development.

Skills

LNP delivery experience

Primary cell culture

Gene editing technologies

Flow cytometry

Nucleic acid QC

Data analysis

Scientific communication

Team collaboration

Education

PhD in Cell Biology or Molecular Biology

MS with 5+ years experience

BS with 7+ years experience

Tools

TapeStation

Qubit

NanoDrop

qPCR

KromaTiD

Optical genome mapping

Job description

Scientist, Genome Sciences & Engineering

Cambridge, Massachusetts, United States

About Stylus Medicine:

Stylus Medicine is developing transformativein vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company’s approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role:

Stylus Medicine is seeking a Scientist to join our Genome Sciences & Engineering team to drive innovation in next-generation gene editing therapies. In this role, the Scientist will drive the in vitro functional assessment of the company’s lead genome editors to support the advancement of the company’s lead programs through translational and preclinical development. This individual will play a key role in discovery and engineering efforts, advancing LSR-based genome editing platforms and collaborating across diverse R&D teams.

Key Responsibilities & Accountabilities:

• Design and execute in vitro functional assays that support candidate selection and preclinical development of lead genome editors,advancing platform and program objectives
• Develop and optimize molecular (ddPCR, qPCR) and cytogenetic (KromaTiD, optical genome mapping) assays to measure genome editor activity, specificity, transgene copy number, TCR repertoire, and biodistribution
• Support genome editor engineering campaigns by running high-throughput screens in relevant cell lines, including primary human T-cells, and delivering timely, decision-quality data to guide candidate selection
• Troubleshoot experiments, analyze data, and translate results into actionable scientific insights
• Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team
• Partner across R&D to advance optimized candidates into translational and preclinical development

Qualifications & Skills:

• PhD in Cell Biology, Molecular Biology, or a related field; or MS with 5+ years or BS with 7+ years of relevant experience
• Hands-on experience with LNP delivery and expertise culturing primary cells (including, but not limited to T-cells and hepatocytes) and/or cancer cell lines
• Working knowledge of gene editing technologies (CRISPR nucleases, recombinases, base editors, or transcriptional effectors)
• Experience with flow cytometry and laboratory automation platforms for cell-based screening workflows
• Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
• Track record of independently generating reproducible data and performing rigorous quantitative analysis
• Strong written and verbal communication skills, with the ability to present complex technical information to both specialist and non-specialist audiences
• Exceptional organizational skills, comfortable managing complex datasets and overlapping projects
• Strategic thinker who plans and prioritizes for scientific impact
• Clear, approachable communicator who makes complex concepts accessible across disciplines
• Collaborative mindset with a team-first attitude
• Decisive problem-solver who thrives amid scientific uncertainty

Pay Range: $125,000 - $140,000

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Stylus Medicine’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.