Scientist 3, Lung Biology & Inflammation

Genentech; San Francisco (CA); Hybride; USD 103 000 - 192 000; Plein temps

Résumé du poste

Genentech’s Immunology Department seeks a Scientist with deep expertise in lung biology and immunology to identify novel therapeutic targets for respiratory diseases. You will lead projects on injury, inflammation, and repair, and push research programs toward early clinical development using state-of-the-art models and analyses.

The role requires a PhD with strong publications, hands-on molecular biology skills, experience with primary cells and flow cytometry, and a track record of

Qualifications

• PhD in immunology, stem cell biology, molecular biology, biochemistry, or a related field with a track record of high-quality publications.
• Deep understanding of lung biology, chronic respiratory diseases, tissue remodeling/regeneration, or host-microbe interactions.
• Hands-on molecular biology including transfections, gene expression profiling, precision genome editing, and targeted RNA delivery.
• Experience with primary cell isolation from human or mouse tissues, in vitro immunological assays, and multi-dimensional flow cytometry.
• Independent design, execution, troubleshooting, and interpretation of complex experiments leading to first-author publications.

Responsabilités

• Lead projects investigating cellular and molecular mechanisms of lung injury, inflammation, and repair.
• Advance research into early clinical development by generating robust proof-of-concept data.
• Utilize in vitro and in vivo models to evaluate novel molecules and delivery systems.
• Dissect pathogenesis of inflammatory lung diseases and determine MOA of therapies.
• Foster collaborations across immunology, human genetics, biomarker discovery, and early clinical development.
• Present findings at internal and cross-departmental meetings.

Description du poste

The Position

Why Genentech

We’re passionate about delivering on Our Promise to improve the lives of patients and create healthier communities for all. We foster a culture of inclusivity, integrity and creativity while boldly pursuing answers to the world’s most complex health challenges and transforming society.

The Opportunity

The Department of Immunology at Genentech is seeking a driven Scientist with deep expertise in lung biology and immunology to uncover novel therapeutic targets for respiratory diseases. In this role, you will lead research projects investigating the cellular and molecular mechanisms underlying the lung's response to injury, chronic inflammation, and repair.

• Lead projects investigating cellular and molecular mechanisms underlying lung injury, chronic inflammation, and tissue repair.
• Advance novel research-stage programs into early clinical development by generating robust proof-of-concept data.
• Utilize state-of-the-art technologies, including in vitro and in vivo models, to evaluate novel molecules and targeted delivery systems.
• Dissect the pathogenesis of inflammatory lung diseases and identify the mechanism of action (MOA) of breakthrough therapies.
• Drive pipeline research while actively exploring new biologies and pathways for target discovery.
• Facilitate fruitful, open collaborations across immunology, human genetics, biomarker discovery, and early clinical development.
• Present research findings effectively at intra- and inter-departmental scientific meetings.

Who you are

• PhD in immunology, stem cell biology, molecular biology, biochemistry, or a related field, with a demonstrated record of high-quality publications.
• Deep understanding of lung biology, particularly in chronic respiratory diseases, tissue remodeling/regeneration, or host-microbe interactions.
• Strong hands-on expertise in molecular biology, including cellular transfections, gene expression profiling, precision genome editing, and targeted RNA delivery technologies.
• Hands-on experience with primary cell isolation from human or mouse tissues, in vitro immunological assays, and multi-dimensional flow cytometry.
• Track record of independently designing, executing, troubleshooting, and interpreting complex experiments leading to first-author publication(s) in top-tier journals.

Preferred

• Proven experience with complex in vitro systems, including airway/alveolar organoids, air-liquid interface (ALI) 3D cultures, or organ-on-a-chip technologies.
• Experience with targeted therapeutic delivery of nucleic acid modalities (e.g., mRNA, siRNA, ASOs) using viral or non-viral vectors.
• Experience with computational data analysis, including scRNA-seq, spatial transcriptomics, or mining public/clinical datasets.

Location

• This role is based in South San Francisco and offers a hybrid schedule working 3 day per week on campus
• No relocation benefits are available for this posting

The expected salary range for this position based on the primary location of CA is $103,400.00 - 192,000.00 USD. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.